Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Analytical Properties of the Nanoelectrospray Ion Source

1996 • 1,816 citations

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1996 • 1,687 citations

Error-Tolerant Identification of Peptides in Sequence Databases by Peptide Sequence Tags

1994 • 1,475 citations

Helicases: amino acid sequence comparisons and structure-function relationships

1993 • 1,141 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Crystal Structures of Complexes of PcrA DNA Helicase with a DNA Substrate Indicate an Inchworm Mechanism

1999 • 793 citations

HeterologousHIS3 Marker and GFP Reporter Modules for PCR-Targeting inSaccharomyces cerevisiae

1997 • 683 citations

Improved Resolution and Very High Sensitivity in MALDI TOF of Matrix Surfaces Made by Fast Evaporation

1994 • 682 citations

RNA Structure Prediction

1988 • 654 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

1998 • 613 citations

TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

1998 • 557 citations

Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families

1999 • 530 citations

D‐E‐A‐D protein family of putative RNA helicases

1992 • 516 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

Structure of the hepatitis C virus RNA helicase domain

1997 • 444 citations

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

1997 • 435 citations

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

1999 • 431 citations

Crystal structure of a DExx box DNA helicase

1996 • 428 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1994 • 384 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p

1999 • 330 citations

Biochemical and Kinetic Characterization of the RNA Helicase Activity of Eukaryotic Initiation Factor 4A

1999 • 326 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

Release of Proteins and Peptides from Fusion Proteins Using a Recombinant Plant Virus Proteinase

1994 • 282 citations

The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.

1993 • 280 citations

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export

1998 • 272 citations

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

1998 • 267 citations

RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

1997 • 250 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway

1997 • 236 citations

Survival of Cholinergic Forebrain Neurons in Developing p75 ^NGFR -Deficient Mice

1996 • 227 citations

A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export

1999 • 222 citations

RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase

1999 • 208 citations

Interactions and three-dimensional localization of a group of nuclear pore complex proteins.

1994 • 206 citations

The DEAD Box Protein eIF4A. 1. A Minimal Kinetic and Thermodynamic Framework Reveals Coupled Binding of RNA and Nucleotide

1998 • 204 citations

Crystal Structure of RNA Helicase from Genotype 1b Hepatitis C Virus

1998 • 202 citations

A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.

1995 • 192 citations

CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm

1999 • 191 citations

The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export

1997 • 171 citations

RNA helicases: modulators of RNA structure

1994 • 169 citations

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.

1995 • 156 citations

The DEAD Box Protein eIF4A. 2. A Cycle of Nucleotide and RNA-Dependent Conformational Changes

1998 • 156 citations

A Look at Messenger RNP Moving through the Nuclear Pore

1997 • 149 citations

Sequential Binding of Import Ligands to Distinct Nucleopore Regions During Their Nuclear Import

1996 • 144 citations

The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate

1995 • 139 citations

G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214.

1996 • 133 citations

Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes.

1990 • 127 citations

PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain.

1998 • 117 citations

Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes

1998 • 116 citations

Overexpression of the Nucleoporin CAN/NUP214 Induces Growth Arrest, Nucleocytoplasmic Transport Defects, and Apoptosis

1998 • 113 citations

New constructs and strategies for efficient PCR-based gene manipulations in yeast

1998 • 91 citations

Functional Characterization of a Nup159p-containing Nuclear Pore Subcomplex

1998 • 90 citations

Hologram-based refractive index detector for capillary electrophoresis: separation of metal ions

1994 • 88 citations

A Lysine Substitution in the ATP-Binding Site of Eucaryotic Initiation Factor 4A Abrogates Nucleotide-Binding Activity

1989 • 75 citations

Identification of five putative yeast RNA helicase genes.

1990 • 66 citations

Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex

1998 • 59 citations

YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity.

1997 • 56 citations

Roles of U4 and U6 snRNAs in the assembly of splicing complexes.

1992 • 52 citations

A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae

1997 • 45 citations

The Nucleoporin CAN/Nup214 Binds to both the Cytoplasmic and the Nucleoplasmic Sides of the Nuclear Pore Complex in Overexpressing Cells

1997 • 22 citations