Role of the Nonsense-Mediated Decay Factor hUpf3 in the Splicing-Dependent Exon-Exon Junction Complex

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

2000 • 923 citations

A Perfect Message

1999 • 807 citations

Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon

2000 • 571 citations

A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing

1998 • 545 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

The pre-mRNA binding K protein contains a novel evolutionary conserved motif

1993 • 526 citations

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

2000 • 514 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

Splicing is required for rapid and efficient mRNA export in metazoans

1999 • 375 citations

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

1997 • 371 citations

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

1998 • 341 citations

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

2000 • 337 citations

Pre-mRNA Splicing Imprints mRNA in the Nucleus with a Novel RNA-Binding Protein that Persists in the Cytoplasm

2000 • 326 citations

Quality Control of mRNA Function

2001 • 326 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins

1997 • 252 citations

REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus

2001 • 248 citations

Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)

2001 • 245 citations

The Double Lives of Shuttling mRNA Binding Proteins

2000 • 240 citations

Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

1998 • 221 citations

A coactivator of pre-mRNA splicing

1998 • 212 citations

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

2001 • 209 citations

Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA

1998 • 200 citations

Nonsense Surveillance in Lymphocytes?

1998 • 200 citations

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

2001 • 180 citations

Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly.

1984 • 177 citations

Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes

2000 • 169 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing

1999 • 146 citations

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

1997 • 144 citations

A monoclonal antibody against 2,2,7‐trimethylguanosine that reacts with intact, class U, small nuclear ribonucleoproteins as well as with 7‐methylguanosine‐capped RNAs

1987 • 133 citations

Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis

1996 • 132 citations

Mammalian orthologues of a yeast regulator of nonsense transcript stability.

1996 • 129 citations

The Acute Myeloid Leukemia-Associated Protein, Dek, Forms a Splicing-Dependent Interaction with Exon-Product Complexes

2000 • 126 citations

Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay

1997 • 114 citations

Association of individual hnRNP proteins and snRNPs with nascent transcripts.

1993 • 113 citations

mRNA quality control: Marking the message for life or death

2001 • 95 citations

A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

1996 • 92 citations

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.

1996 • 66 citations

Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3′ end processing of the corresponding pre-mRNA

1999 • 49 citations

A Premature Termination Codon Interferes with the Nuclear Function of an Exon Splicing Enhancer in an Open Reading Frame-Dependent Manner

1999 • 33 citations