Positron emission tomography and single-photon emission computed tomography in substance abuse research

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1987 • 2,189 citations

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Brain dopamine and obesity

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Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

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MONOAMINE OXIDASE: From Genes to Behavior

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Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers

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Decreased dopamine D₂ receptor availability is associated with reduced frontal metabolism in cocaine abusers

1993 • 906 citations

Low Level of Brain Dopamine D₂ Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex

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Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

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Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence

2001 • 730 citations

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1996 • 704 citations

Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings

1998 • 673 citations

Inhibition of monoamine oxidase B in the brains of smokers

1996 • 666 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

MicroPET: a high resolution PET scanner for imaging small animals

1997 • 610 citations

Decreases in Dopamine Receptors but not in Dopamine Transporters in Alcoholics

1996 • 603 citations

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1992 • 466 citations

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1996 • 427 citations

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Effects of chronic cocaine abuse on postsynaptic dopamine receptors

1990 • 407 citations

Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D₂ Receptor Levels

1999 • 406 citations

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1999 • 403 citations

Methamphetamine-Related Psychiatric Symptoms and Reduced Brain Dopamine Transporters Studied With PET

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Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography

1988 • 368 citations

Overexpression of dopamine D2 receptors reduces alcohol self‐administration

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Reduced Central Serotonin Transporters in Alcoholism

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Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain

1990 • 308 citations

Mapping cocaine binding sites in human and baboon brain in vivo

1989 • 300 citations

(±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates

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Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal

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1996 • 263 citations

PET evaluation of the dopamine system of the human brain.

1996 • 249 citations

Sex differences in [¹²³I]β‐CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers

2001 • 245 citations

Higher Cortical and Lower Subcortical Metabolism in Detoxified Methamphetamine Abusers

2001 • 245 citations

Neural responses associated with cue evoked emotional states and heroin in opiate addicts

2000 • 234 citations

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Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication

1996 • 218 citations

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography

1992 • 211 citations

Recovery of brain glucose metabolism in detoxified alcoholics

1994 • 201 citations

Cortical Serotonin Transporter Density and Verbal Memory in Individuals Who Stopped Using 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy")

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A novel strategy for the treatment of cocaine addiction

1998 • 196 citations

Acute effects of ethanol on regional brain glucose metabolism and transport

1990 • 182 citations

Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain

2000 • 179 citations

Effect of nicotine on brain activation during performance of a working memory task

2001 • 176 citations

A pharmacologic strategy for the treatment of nicotine addiction

1999 • 176 citations

Effects of Smoking Marijuana on Brain Perfusion and Cognition

2002 • 169 citations

High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers

2000 • 165 citations

Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.

1996 • 163 citations

Brain perfusion is abnormal in cocaine-dependent polydrug users: a study using technetium-99m-HMPAO and ASPECT.

1991 • 163 citations

Changes in Regional Cerebral Blood Flow Elicited by Craving Memories in Abstinent Opiate-Dependent Subjects

2001 • 161 citations

Reduced levels of GABA-benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy

1998 • 140 citations

Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, ?ecstasy?) and its congeners

1997 • 138 citations

Dopamine transporters increase in human brain after alcohol withdrawal

1999 • 137 citations

Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers

2001 • 136 citations

Morphine-Induced Metabolic Changes in Human Brain

1990 • 130 citations

Decreased cerebral response to inhibitory neurotransmission in alcoholics

1993 • 123 citations

Changes in brain activation associated with reward processing in smokers and nonsmokers

2001 • 123 citations

Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study

2000 • 122 citations

Imaging the Brain Marijuana Receptor: Development of a Radioligand that Binds to Cannabinoid CB1 Receptors In Vivo

1998 • 122 citations

Buprenorphine-Induced Changes in Mu-Opioid Receptor Availability in Male Heroin-Dependent Volunteers A Preliminary Study

2000 • 122 citations

Cerebellar activity and disturbed time sense after THC

1998 • 111 citations

Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts.

2000 • 110 citations

Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients

2000 • 110 citations

Positron emission tomographic studies of cerebral benzodiazepine‐receptor binding in chronic alcoholics

1996 • 106 citations

Changes in reward‐induced brain activation in opiate addicts

2001 • 99 citations

Isolation and Characterization of a Monoamine Oxidase Inhibitor from Tobacco Leaves

1999 • 98 citations

Dopamine transporter and D 2 -receptor density in late-onset alcoholism

1999 • 97 citations

Neuroimaging in Alcoholism: Ethanol and Brain Damage

2001 • 96 citations

Neuroimaging in Alcoholism: Ethanol and Brain Damage

2001 • 95 citations

Cerebellar metabolic activation by delta-9-tetrahydrocannabinol in human brain: A study with positron emission tomography and 18F-2-Fluoro-2-deoxyglucose

1991 • 95 citations

Cerebellar hypoactivity in frequent marijuana users

2000 • 94 citations

Striatal Dopaminergic D₂ Receptor Density Measured by [¹²³I]Iodobenzamide SPECT in the Prediction of Treatment Outcome of Alcohol-Dependent Patients

2000 • 94 citations

Regional Brain Metabolism During Alcohol Intoxication

2000 • 93 citations

Regional cerebral blood flow effects of nicotine in overnight abstinent smokers

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Development of ligands for in vivo imaging of cerebral nicotinic receptors

2000 • 90 citations

Regional Brain Metabolic Response to Lorazepam in Subjects at Risk for Alcoholism

1995 • 89 citations

Monoamine oxidase: radiotracer development and human studies

2002 • 78 citations

Acute cocaine effects on absolute cerebral blood flow

1996 • 78 citations

Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers

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Hidden persuasion

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Distribution and kinetics of carbon-11-cocaine in the human body measured with PET.

1992 • 67 citations

Acute marijuana effects on rCBF and cognition

2000 • 65 citations

Long-term effects of ‘ecstasy’ abuse on the human brain studied by FDG PET

2001 • 65 citations

Pathological Regional Cerebral Blood Flow in Opiate-Dependent Patients during Withdrawal: A HMPAO-SPECT Study

1998 • 65 citations

Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in healthy human subjects

2001 • 64 citations

Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[¹¹C]Dihydrotetrabenazine and positron emission tomography

1998 • 64 citations

Regional cerebral blood flow changes in chronic alcoholic patients induced by naltrexone challenge during detoxification.

1999 • 63 citations

Fluoro-norchloroepibatidine: Preclinical assessment of acute toxicity

1997 • 61 citations

Synthesis and evaluation of 6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors

2000 • 53 citations

Localization of neurochemical effects of cocaine and other stimulants in the human brain.

1988 • 52 citations

Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET

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Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice

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Brain SPECT findings in long-term inhalant abuse

2000 • 40 citations

In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET.

2002 • 38 citations

Levels of γ‐Aminobutyric Acid‐Benzodiazepine Receptors in Abstinent, Alcohol‐Dependent Women: Preliminary Findings From an ¹²³I‐Iomazenil Single Photon Emission Tomography Study

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Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.

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PET Imaging Studies in Drug Abuse

1998 • 34 citations

Monoamine Oxidase: Radiotracer Development and Human Studies

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Pet studies of cocaine inhibition of myocardial norepinephrine uptake

1994 • 28 citations

Regional cerebral blood flow abnormalities in chronic solvent abusers

1999 • 28 citations

Imaging the neurochemistry of nicotine actions: Studies with positron emission tomography

1999 • 28 citations

Occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette

2000 • 25 citations

Regional Cerebral Metabolism in Female Alcoholics of Moderate Severity Does Not Differ From That of Controls

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Effects of active chronic cocaine use on cardiac sympathetic neuronal function assessed by carbon-11-hydroxyephedrine.

1997 • 11 citations

Detection of hepatoma in liver cirrhosis

1977 • 6 citations