A pharmacologic strategy for the treatment of nicotine addiction

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

1997 • 1,273 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

1994 • 741 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis

1984 • 576 citations

Basic and Clinical Pharmacology

1984 • 538 citations

Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

1994 • 524 citations

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

1998 • 502 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

Conditioned responses to cocaine-related stimuli in cocaine abuse patients

1992 • 457 citations

Nicotinic effects on the firing pattern of midbrain dopamine neurons

1986 • 399 citations

Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens

1998 • 382 citations

Nicotine Medications for Smoking Cessation

1995 • 366 citations

Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine

1981 • 341 citations

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

1998 • 329 citations

Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

1988 • 313 citations

Vigabatrin

1991 • 309 citations

Endogenous dopamine lowers the dopamine D₂ receptor density as measured by [³H]raclopride: Implications for positron emission tomography of the human brain

1989 • 298 citations

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine‐Treated Rats

1997 • 288 citations

Striatal binding of the PET ligand ¹¹C‐raclopride is altered by drugs that modify synaptic dopamine levels

1993 • 285 citations

Conditioning factors in opiate addiction and relapse

1984 • 279 citations

Selective dopamine antagonists reduce nicotine self-administration

1991 • 279 citations

The biological, social and clinical bases of drug addiction: commentary and debate

1996 • 277 citations

Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine

1987 • 275 citations

Brain reward systems and abuse

1988 • 274 citations

Nicotine self-administration in rats

1995 • 228 citations

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography

1992 • 211 citations

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release

1994 • 204 citations

A novel strategy for the treatment of cocaine addiction

1998 • 196 citations

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats

1996 • 196 citations

The use of place conditioning in studying the neuropharmacology of drug reinforcement

1989 • 193 citations

The Neuropharmacological Basis of Reward

1992 • 193 citations

Pharmacologic characterization of nicotine-induced conditioned place preference

1985 • 191 citations

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs

1987 • 175 citations

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens

1989 • 174 citations

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen

1990 • 162 citations

A learning model of addiction.

1992 • 159 citations

Cigarette smokers self-administer intravenous nicotine

1983 • 157 citations

Stimulation of [³H]Dopamine Release by Nicotine in Rat Nucleus Accumbens

1987 • 154 citations

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure

1997 • 150 citations

GABAB receptors in mammalian function

1991 • 146 citations

Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

1990 • 142 citations

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders

1995 • 142 citations

Self-administration in rats allowed unlimited access to nicotine

1997 • 130 citations

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.

1993 • 128 citations

Trends in cigarette smoking in the United States: The Epidemiology of Tobacco Use

1992 • 127 citations

Euphoriant effects of nicotine in smokers

1992 • 118 citations

Control of behavior by intravenous nicotine injections in human subjects

1983 • 117 citations

GABAergic attenuation of cocaine-induced dopamine release and locomotor activity

1997 • 116 citations

(?)-nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

1997 • 116 citations

Further studies on nicotine-induced conditioned place preference in the rat

1986 • 110 citations

Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine

1998 • 98 citations

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats

1996 • 90 citations

Synthesis of [methoxy‐³H]‐ and [methoxy‐¹¹C]‐ labelled raclopride. Specific dopamine‐D₂ receptor ligands

1987 • 85 citations

Apparent absence of nicotine-induced conditioned place preference in rats

1987 • 83 citations

NICOTINE SELF‐ADMINISTRATION IN MONKEYS*

1967 • 81 citations

Bupropion sustained release and smoking cessation.

1998 • 81 citations

Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of nicotine in the rat

1982 • 78 citations

Role of Conditioning Factors in the Development of Drug Dependence

1986 • 76 citations

The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.

1995 • 75 citations

In vivo Amygdala Dopamine Levels Modulate Cocaine Self‐administration Behaviour in the Rat: D1 Dopamine Receptor Involvement

1997 • 73 citations

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds

1997 • 71 citations

Pharmacological treatment of tobacco dependence

1988 • 70 citations

GABAB receptors as targets for drug action.

1992 • 66 citations

Addiction Mortality in the United States, 1980: Tobacco, Alcohol, and Other Substances

1984 • 62 citations

Implication of the GABAb receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine

1999 • 57 citations

Extinction of conditioned responses in abstinent cocaine or opioid users.

1987 • 55 citations

Selective stimulation of limbic dopamine activity by nicotine

1988 • 51 citations

Increases in dopamine utilization in certain limbic dopamine terminal populations after a short period of intermittent exposure of male rats to cigarette smoke

1986 • 51 citations

The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus

1998 • 38 citations

The Role of the Addictive Process as a Key Step in Causation of All Tobacco-Related Diseases

1984 • 34 citations

The Study of Neurotransmitter Interactions Using Positron Emission Tomography and Functional Coupling

1996 • 19 citations

Drug dependence study on vigabatrin in rhesus monkeys and rats.

1997 • 15 citations

Nicotine Boost Per Cigarette as the Controlling Factor of Intake Regulation by Smokers

1995 • 11 citations

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