Decreases in Dopamine Receptors but not in Dopamine Transporters in Alcoholics

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Decreased dopamine D₂ receptor availability is associated with reduced frontal metabolism in cocaine abusers

1993 • 906 citations

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

1986 • 847 citations

The familial incidence of alcoholism: a review.

1979 • 817 citations

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

1991 • 656 citations

Effects of chronic cocaine abuse on postsynaptic dopamine receptors

1990 • 407 citations

Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption.

1991 • 375 citations

Stress and Alcohol Interaction: An Update of Human Research

1991 • 345 citations

Alcoholism and Heredity

1979 • 319 citations

Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats

1990 • 301 citations

NO Association Between an Allele at the D2 Dopamine Receptor Gene (DRD2) and Alcoholism

1991 • 297 citations

Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats

1987 • 289 citations

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour

1995 • 274 citations

Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence

1994 • 268 citations

Dopamine transporters decrease with age.

1996 • 257 citations

PET evaluation of the dopamine system of the human brain.

1996 • 249 citations

Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism

1991 • 218 citations

Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics

1995 • 216 citations

Neuropeptides in Neurologic and Psychiatric Disease

1987 • 203 citations

Recovery of brain glucose metabolism in detoxified alcoholics

1994 • 201 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Effects of Blood Flow on [¹¹C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data

1994 • 171 citations

Involvement of corticosterone in the modulation of ethanol consumption in the rat

1994 • 156 citations

Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: Antagonism by diazepam

1982 • 137 citations

Genetics and the Risk for Alcoholism

1985 • 133 citations

D2 Dopamine Receptor Gene Is Associated but Not Linked With Alcoholism

1991 • 133 citations

Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism

1992 • 126 citations

Decreased cerebral response to inhibitory neurotransmission in alcoholics

1993 • 123 citations

A new PET ligand for the dopamine transporter: studies in the human brain.

1995 • 121 citations

D₂ dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5‐hydroxyindoleacetic acid and 3‐methoxy‐4‐hydroxyphenylglycol in alcoholics in Finland and the United States

1992 • 107 citations

Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain.

1975 • 106 citations

Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.

1995 • 103 citations

Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142

1985 • 101 citations

Social structure and ethanol consumption in the laboratory rat

1987 • 99 citations

Alcohol and Alcoholism

1980 • 94 citations

Movement disorders in alcoholism

1990 • 84 citations

Decreased Neuronal Inhibition in Vitro After Long-Tterm Administration of Ethanol

1984 • 79 citations

Neuroendocrine Evidence for Reduced Dopamine Receptor Sensitivity in Alcoholism

1992 • 67 citations

Current Excitement With D2 Dopamine Receptor Gene Alleles in Substance Abuse

1992 • 67 citations

Further neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholism

1993 • 62 citations

Alcohol and neurobiology : receptors, membranes, and channels

1992 • 61 citations

Dopaminergic responsivity in alcoholism: trait, state, or residual marker?

1995 • 60 citations

Dopamine and Noradrenaline Content in the Brain of Rat Strains Selected for their Alcohol Intake

1975 • 60 citations

Parkinsonism provoked by alcoholism

1981 • 59 citations

Changes in dopamine receptor sensitivity in humans after heavy alcohol intake

1985 • 58 citations

PET analysis of [11C]flumazenil binding to benzodiazepine receptors in chronic alcohol-dependent men and healthy controls

1993 • 58 citations

Biochemical evidence for activation of specific monoanine pathways by ethanol

1988 • 55 citations

Loss of muscarinic and benzodiazepine neuroreceptors from hippocampus of alcohol abusers

1989 • 54 citations

Plasma GABA levels in chronic alcoholics

1985 • 46 citations

Neurochemical correlates of alcohol preference in inbred strains of mice

1975 • 43 citations

Blockade by Diazepam of conditioned fear-induced activation of rat mesoprefrontal dopamine neurons

1989 • 40 citations

Neuroleptic-induced akathisia and dystonia triggered by alcohol.

1976 • 38 citations

Transient Choreiform Dyskinesias During Alcohol Withdrawal

1982 • 31 citations

GENETIC DIFFERENCES IN THE EFFECTS OF VOLUNTARY ETHANOL CONSUMPTION ON BRAIN MONOAMINE LEVELS IN INBRED STRAINS OF MICE, C57BL/6J, C3H/He AND DBA/2Cr

1989 • 30 citations

Neuroleptic-lnduced Akathisia and Dystonia Triggered by Alcohol

1976 • 29 citations

Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome

1983 • 25 citations

Suppressed ethanol intake by CER following the sucrose-fading initiation procedure

1988 • 5 citations