Monoamine Oxidase: Radiotracer Development and Human Studies

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 • 1,620 citations

Some observations upon a new inhibitor of monoamine oxidase in brain tissue

1968 • 1,589 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Smoking, Smoking Cessation, and Major Depression

1990 • 1,174 citations

MONOAMINE OXIDASE: From Genes to Behavior

1999 • 1,154 citations

Prevalence of smoking among psychiatric outpatients

1986 • 1,059 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease

1989 • 913 citations

cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

1988 • 713 citations

Neocortical cell counts in normal human adult aging

1987 • 676 citations

Inhibition of monoamine oxidase B in the brains of smokers

1996 • 666 citations

Ginkgo Biloba

1996 • 622 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Some puzzling pharmacological effects of monoamine oxidase inhibitors.

1972 • 561 citations

Ginkgo biloba

1992 • 451 citations

Suicide substrates: mechanism-based enzyme inactivators

1982 • 443 citations

Brain monoamine oxidase A inhibition in cigarette smokers

1996 • 427 citations

Mapping Human Brain Monoamine Oxidase A and B with ¹¹ C-Labeled Suicide Inactivators and PET

1987 • 388 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

Suicide enzyme inactivators

1976 • 366 citations

Increased monoamine oxidase b activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

1994 • 361 citations

Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstem

1988 • 347 citations

The effect of age on the activity and molecular properties of human brain monoamine oxidase

1980 • 342 citations

Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19- 6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain

1992 • 332 citations

Relation of Sex and Aging to Monoamine Oxidase Activity of Human Brain, Plasma, and Platelets

1971 • 288 citations

Tyramine oxidase

1928 • 276 citations

Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type

1980 • 254 citations

Increased stress response and β–phenylethylamine in MAOB–deficient mice

1997 • 254 citations

Monoamine Oxidase Activity and Monoamine Metabolism in Brains of Parkinsonian Patients Treated with l‐Deprenyl

1986 • 243 citations

Involvement of tobacco in alcoholism and illicit drug use

1990 • 239 citations

Age-Related Increases in Brain Monoamine Oxidase B in Living Healthy Human Subjects

1997 • 238 citations

Smoking and Parkinson’s disease

1999 • 222 citations

AMINE OXIDASES

1955 • 183 citations

Relationship between cigarette smoking and Alzheimer's disease in a population‐based case‐control study

1993 • 179 citations

Monoamine neurons in aging and Alzheimer's disease

1993 • 175 citations

Über den enzymatischen Abbau von Histamin und Diaminen. 2. Mitteilung

1938 • 168 citations

A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers*

1995 • 167 citations

Monoamine oxidase, brain ageing and degenerative diseases

1989 • 155 citations

Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.

1995 • 155 citations

Monoamine oxidase inhibitors and the cheese effect

1993 • 150 citations

The inactivation of adrenaline

1937 • 149 citations

Slow recovery of human brain MAO B after L‐Deprenyl (Selegeline) withdrawal

1994 • 146 citations

Monoamine oxidase A and B activities in heavy smokers

1995 • 140 citations

Rescue of axotomized immature rat facial motoneurons by R(-)-deprenyl: stereospecificity and independence from monoamine oxidase inhibition

1993 • 140 citations

Low platelet monoamine oxidase activity in cigarette smokers

1981 • 130 citations

Expression of monoamine oxidase B activity in astrocytes of senile plaques

1990 • 128 citations

Effect of Long‐Term Treatment with Selective Monoamine Oxidase A and B Inhibitors on Dopamine Release from Rat Striatum In Vivo

1996 • 127 citations

Turnover of Brain Monoamine Oxidase Measured In Vivo by Positron Emission Tomography Using <scp>l</scp>‐[¹¹C]Deprenyl

1987 • 119 citations

The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase

1976 • 119 citations

TREATMENT OF PULMONARY TUBERCULOSIS WITH HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID

1952 • 119 citations

Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease

1988 • 116 citations

Extracts of ginkgo biloba leaves inhibit monoamine oxidase

1996 • 112 citations

Differential age-related changes of mao-a and mao-b in mouse brain and pe peripheral organs

1994 • 109 citations

Measurement of human cerebral monoamine oxidase type B (MAO-B) activity with positron emission tomography (PET): a dose ranging study with the reversible inhibitor Ro 19-6327

1991 • 105 citations

Monoamine Oxidase and Mitochondrial Respiration

1999 • 105 citations

Effects of endogenous dopamine on measures of [¹⁸F]N‐methylspiroperidol binding in the basal ganglia: Comparison of simulations and experimental results from PET studies in baboons

1991 • 105 citations

A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation

2003 • 104 citations

Effect of lazabemide on the progression of disability in early Parkinson's disease

1996 • 104 citations

Mechanistic Positron Emission Tomography Studies: Demonstration of a Deuterium Isotope Effect in the Monoamine Oxidase‐Catalyzed Binding of [¹¹C]l‐Deprenyl in Living Baboon Brain

1988 • 103 citations

Therapeutic Value of Ginkgo biloba in Reducing Symptoms of Decline in Mental Function

1999 • 101 citations

THE PSYCHIATRIC SIDE-EFFECTS OF IPRONIAZID

1956 • 99 citations

Isolation and Characterization of a Monoamine Oxidase Inhibitor from Tobacco Leaves

1999 • 98 citations

DEUTERIUM ISOTOPE EFFECTS IN RELATION TO THE CHEMICAL MECHANISM OF MONOAMINE OXIDASE*

1963 • 95 citations

The molecular pharmacology of L-deprenyl

1992 • 95 citations

Localization of monoamine oxidases in human peripheral tissues

1996 • 95 citations

Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors

1985 • 92 citations

Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease

1993 • 83 citations

Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.

1999 • 80 citations

11C-harmine as a tracer for monoamine oxidase a (MAO-A): In vitro and in vivo studies

1997 • 75 citations

Hidden persuasion

1996 • 74 citations

Platelet monoamine oxidase activity and psychopathy

1985 • 74 citations

Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes

1992 • 73 citations

Platelet monoamine oxidase: Low activity in cigarette smokers

1987 • 70 citations

Measurement of Cerebral Monoamine Oxidase B Activity Using L-[¹¹C]Deprenyl and Dynamic Positron Emission Tomography

1991 • 69 citations

Maintenance of Brain Monoamine Oxidase B Inhibition in Smokers After Overnight Cigarette Abstinence

2000 • 68 citations

Monoamine oxidases: old friends hold many surprises

1995 • 65 citations

Potential Metabolic Bioactivation Pathways Involving Cyclic Tertiary Amines and Azaarenes

1997 • 65 citations

Synthesis of suicide inhibitors of monoamine oxidase: Carbon‐11 labeled clorgyline, L‐deprenyl and D‐deprenyl

1988 • 65 citations

Selective, irreversible in vivo binding of [11C]clorgyline and [11C]-L-deprenyl in mice: Potential for measurement of functional monoamine oxidase activity in brain using positron emission tomography

1985 • 64 citations

Characterization of phentermine and related compounds as monoamine oxidase (mao) inhibitors

2000 • 60 citations

Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain

1997 • 58 citations

Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics

1998 • 57 citations

Positron Emission Tomography with [¹¹C]Deuterium‐Deprenyl in Temporal Lobe Epilepsy

1995 • 57 citations

THE DRAMBALLET STUDIO

1996 • 54 citations

Plasma input function determination for PET using a commercial laboratory robot

1995 • 53 citations

Treatment of Negative Symptoms in Schizophrenia and Schizoaffective Disorder by Selegiline Augmentation of Antipsychotic Medication

1996 • 52 citations

Dopamine metabolism and neurotransmission in primate brain in relationship to monoamine oxidase A and B inhibition

1993 • 52 citations

In Vitro Quantitative Autoradiography of [³H]‐L‐Deprenyl and [³H]‐PK 11195 Binding Sites in Human Epileptic Hippocampus

1992 • 52 citations

Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers

1999 • 49 citations

MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography

1997 • 47 citations

Monoamine oxidase, dopamine and Parkinson's disease

1991 • 45 citations

Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain

2000 • 43 citations

Selegiline Effects on Cocaine-Induced Changes in Medial Temporal Lobe Metabolism and Subjective Ratings of Euphoria

1999 • 43 citations

Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex

1995 • 43 citations

An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo

1998 • 41 citations

Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl, (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and PET studies in baboon brain

1990 • 40 citations

Non‐MAO A binding of clorgyline in white matter in human brain

2001 • 34 citations

Schizophrenia, Monoamine Oxidase Activity, and Cigarette Smoking

1999 • 32 citations

PET imaging of monoamine oxidase B in peripheral organs in humans.

2002 • 31 citations

Mechanistic Positron Emission Tomography Studies of 6‐[¹⁸F]Fluorodopamine in Living Baboon Heart: Selective Imaging and Control of Radiotracer Metabolism Using the Deuterium Isotope Effect

1995 • 30 citations

Radioactive N,N‐Dimethylphenylethylamine: A Selective Radiotracer for In Vivo Measurement of Monoamine Oxidase‐B Activity in the Brain

1985 • 30 citations

Species differences in [ 11 C]clorgyline binding in brain

2001 • 29 citations

Synthesis and in vivo studies of a specific monoamine oxidase B inhibitor: 5-[4-(benzyloxy)phenyl]-3-(2-cyanoethyl)-1,3,4-oxadiazol-[11C]-2(3H)-one

1996 • 29 citations

Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

2000 • 29 citations

Sensitivity of [11C]phenylephrine kinetics to monoamine oxidase activity in normal human heart.

1999 • 29 citations

Biodistribution of a positron-emitting suicide inactivator of monoamine oxidase, carbon-11 pargyline, in mice and a rabbit.

1985 • 28 citations

Kinetics of [11C]N,N-dimethylphenylethylamine in mice and humans: potential for measurement of brain MAO-B activity.

1987 • 27 citations

Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice

1999 • 26 citations

Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology

1998 • 25 citations

Evidence that l-deprenyl treatment for one week does not inhibit mao a or the dopamine transporter in the human brain

2001 • 23 citations

Clinical and biochemical aspects of depressive disorders: III. Treatment and controversies

1992 • 23 citations

Deprenyl prolongs the therapeutic efficacy of combined L-DOPA in Parkinson's disease.

1984 • 22 citations

11C-labelling of dimethylphenethylamine in two different positions and biodistribution studies

1989 • 21 citations

The in vitro insertion of monoamine oxidase B into mitochondrial outer membranes

1988 • 20 citations

Monoamine oxidase B single-photon emission tomography with [ 123 I]Ro 43-0463: imaging in volunteers and patients with temporal lobe epilepsy

1998 • 17 citations

Catecholamines and Blood Pressure Regulation

1990 • 17 citations

In Vivo properties of N-(2-aminoethyl)-5-halogeno-2-pyridinecarboxamide 18F- and 123I-labelled reversible inhibitors of monoamine oxidase B

1998 • 16 citations

MAO-A ENZYME BINDING IN BLADDER-CANCER CHARACTERIZED WITH [C-11] HARMINE IN FROZEN-SECTION AUTORADIOGRAPHY

1995 • 16 citations

Development of N-[3-(2′,4′-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A

1999 • 13 citations

Comparison of Brain Glucose Metabolism and Monoamine Oxidase B (MAO B) in Traumatic Brain Injury

1999 • 13 citations

Radiosynthesis of [11C]brofaromine, a potential tracer for imaging monoamine oxidase A

1996 • 12 citations

Evaluation of a Ginkgo biloba Extract (EGb 761) in Functional Tests for Monoamine Oxidase Inhibition

2011 • 11 citations

Evaluation of radioiodinated iodoclorgyline as a SPECT radiopharmaceutical for MAO-A in the brain

1995 • 11 citations

[13N]-β-phenethylamine ([13N]PEA): A prototype tracer for measurement of MAO-B activity in heart

1987 • 11 citations

[] N-(2-aminoethyl)-5-halogeno-2-pyridinecarbox-amides, site specific tracers for MAO-B mapping with SPET and PET

1995 • 10 citations

Deuterium isotope effect of [ 11 C 1 ]N, N-dimethylphenethyl-amine-α, α-d 2 ; reduction in metabolic trapping rate in brain

1986 • 10 citations

Iododerivative of pargyline: A potential tracer for the exploration of monoamine oxidase sites by SPECT

1995 • 9 citations

An iodinated derivative of moclobemide as potential radioligand for brain MAO-A exploration

1996 • 7 citations

123I-labeling and evaluation of Ro 43–0463, a spet tracer for MAO-B imaging

1995 • 7 citations

Selegiline HC1: Selective MAO-type B inhibitor.

1990 • 5 citations

Deleted Work

1955 • 0 citations