SingleH2Kb, H2Db and doubleH2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice

1997 • 486 citations

Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

1994 • 275 citations

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

1986 • 212 citations

H-2M3 presents a listeria monocytogenes peptide to cytotoxic T lymphocytes

1992 • 203 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

LCMV-Specific, Class II-Restricted Cytotoxic T Cells in β2-Microglobulin-Deficient Mice

1992 • 164 citations

Molecules Related to Class-I Major Histocompatibility Complex Antigens

1990 • 146 citations

Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.

1992 • 146 citations

A nonpolymorphic class I gene in the murine major histocompatibility complex

1984 • 146 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Specialized Role for a Murine Class I-b MHC Molecule in Prokaryotic Host Defenses

1992 • 135 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells.

1991 • 112 citations

Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: Inactivation of the mouseERCC-1 gene

1992 • 111 citations

Dominance of a single peptide bound to the class I(B) molecule, Qa-1b.

1997 • 103 citations

A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides.

1994 • 99 citations

Model for the in vivo assembly of nascent Ld class I molecules and for the expression of unfolded Ld molecules at the cell surface.

1993 • 97 citations

The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.

1994 • 97 citations

Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules

1993 • 94 citations

The Signal Sequence of Lymphocytic Choriomeningitis Virus Contains an Immunodominant Cytotoxic T Cell Epitope That Is Restricted by both H-2Dband H-2KbMolecules

1997 • 84 citations

Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.

1992 • 70 citations

Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.

1995 • 70 citations

MHC class Ib-restricted cells contribute to antilisterial immunity: evidence for Qa-1b as a key restricting element for Listeria-specific CTLs.

1997 • 69 citations

Qa‐1 interaction and T cell recognition of the Qa‐1 determinant modifier peptide

1997 • 63 citations

Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins

1993 • 58 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.

1984 • 57 citations

Development and antigen specificity of CD8+ cytotoxic T lymphocytes in beta 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells.

1994 • 41 citations

Transfer of lymphocytic choriomeningitis disease in β₂-microglobulin-deficient mice by CD4⁺ T cells

1993 • 41 citations

Differential reactivity of residual CD8⁺ T lymphocytes in TAP1 and β2‐microglobulin mutant mice

1995 • 39 citations

Expression of the thymus leukemia antigen by activated peripheral T lymphocytes.

1983 • 37 citations

Peptide binding to the class Ib molecule, Qa-1b.

1997 • 36 citations

Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies.

1989 • 35 citations

Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice.

1995 • 30 citations

Thymic education - T cells do it for themselves

1994 • 21 citations

The alpha 3 domain of the Qa-2 molecule is defective for CD8 binding and cytotoxic T lymphocyte activation.

1993 • 19 citations

Maturation of Qa-1b Class I Molecules Requires β2-Microglobulin But Is TAP Independent

1998 • 17 citations

Maturation of Qa-1b class I molecules requires beta 2-microglobulin but is TAP independent.

1998 • 17 citations

Rapid enrichment of mouse natural killer cells by use of wheat germ agglutinin

1983 • 17 citations

CD4+ and CD8+ alpha beta, and gamma delta T cells are cytotoxic effector cells of beta 2-microglobulin-deficient mice against cells having normal MHC class I expression.

1994 • 15 citations

Unprimed T cells are inefficiently stimulated by glycosylphosphatidylinositol-linked H-2K^b because of its lipid anchor rather than defects in CD8 binding

1996 • 4 citations