Highly Conserved RNA Sequences That Are Sensors of Environmental Stress

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Plasticity of the Differentiated State

1985 • 839 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency

1985 • 645 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

1996 • 541 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

1986 • 533 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Translational regulation in development

1995 • 394 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

1991 • 349 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

1997 • 314 citations

A conserved family of elav-like genes in vertebrates.

1995 • 309 citations

Two functional complexes formed by KH domain containing proteins with the 5' noncoding region of poliovirus RNA.

1997 • 298 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Differentiation requires continuous regulation.

1991 • 276 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

Tetracycline-Reversible Silencing of Eukaryotic Promoters

1995 • 271 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

RNA Structure and Function

2023 • 264 citations

Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity

1997 • 261 citations

Genetic complementation reveals a novel regulatory role for 3? untranslated regions in growth and differentiation

1993 • 245 citations

Efficient screening of retroviral cDNA expression libraries.

1995 • 244 citations

Searching for regulatory elements in human noncoding sequences

1997 • 242 citations

The Basics of Molecular Biology

1986 • 231 citations

Toso, a Cell Surface, Specific Regulator of Fas-Induced Apoptosis in T Cells

1998 • 224 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin

1993 • 201 citations

Mechanisms Controlling the Transcription of Matrix Metalloproteinase Genes in Normal and Neoplastic Cells

1996 • 194 citations

Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression

1993 • 160 citations

DIFFERENTIATION REQUIRES CONTINUOUS ACTIVE CONTROL

1992 • 158 citations

Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region.

1990 • 154 citations

The 5'- and 3'-untranslated regions of ornithine decarboxylase mRNA affect the translational efficiency.

1990 • 146 citations

Erythroid cell-specific determinants of alpha-globin mRNA stability.

1994 • 145 citations

RNA-RNA Interactions in Nuclear Pre-mRNA Splicing

1998 • 137 citations

U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation.

1992 • 135 citations

mRNA metabolism and post-transcriptional gene regulation

1997 • 129 citations

In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.

1996 • 100 citations

Mechanisms of translational control in early development

1996 • 95 citations

A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation.

1992 • 94 citations

Graded transcriptional response to different concentrations of a single transactivator

1998 • 94 citations

Control of the Translational Efficiency of β-ATPase mRNA Depends on the Regulation of a Protein That Binds the 3′ Untranslated Region of the mRNA

1997 • 91 citations

High-efficiency retroviral infection of primary myoblasts

1997 • 78 citations

Post-transcriptional Regulation of Erythropoietin mRNA Stability by Erythropoietin mRNA-binding Protein

1997 • 76 citations

Differential Effects of Polyadenylation Regions on Gene Expression in Mammalian Cells

1986 • 75 citations

Reversal of Creatine Kinase Translational Repression by 3′ Untranslated Sequences

1990 • 69 citations

Separate Domains of the Ran GTPase Interact with Different Factors To Regulate Nuclear Protein Import and RNA Processing

1995 • 68 citations

Sequencing of the human vascular endothelial growth factor (VEGF) 3′ untranslated region (UTR): conservation of five hypoxia-inducible RNA-protein binding sites

1997 • 66 citations

Conservation of the C.elegans tra-2 3'UTR translational control

1997 • 63 citations

Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation.

1992 • 55 citations

Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.

1997 • 52 citations

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene

1992 • 51 citations

A novel transforming growth factor-β₁responsive cytoplasmic frans-acting factor binds selectively to the 3′-untranslated region of mammalian ribonucleotide reductase R2 mRNA: role in message stability

1993 • 51 citations

AU-rich mRNA instability elements on human papillomavirus type 1 late mRNAs and c-fos mRNAs interact with the same cellular factors

1997 • 48 citations

Erythroid Cell-Specific Determinants of α-Globin mRNA Stability

1994 • 43 citations

Extremely Stable Transcripts May Compensate for the Elimination of the Gene fert-1 from All Ascaris lumbricoides Somatic Cells

1994 • 42 citations

RNA-protein interactions within the 3 ' untranslated region of vimentin mRNA

1997 • 39 citations

Translational regulation of the heat shock response

1994 • 39 citations

Tissue-specific expression of Ran isoforms in the mouse

1994 • 38 citations

U-Rich Sequence-Binding Proteins (URBPs) Interacting with a 20-Nucleotide U-Rich Sequence in the 3′ Untranslated Region of c-fos mRNA May Be Involved in the First Step of c-fos mRNA Degradation

1992 • 35 citations

11 Masked and Translatable Messenger Ribonucleoproteins in Higher Eukaryotes

1996 • 31 citations

RNA Structures Involved in Selenoprotein Synthesis

1998 • 30 citations

The 3′-Untranslated Region of the α2C-Adrenergic Receptor mRNA Impedes Translation of the Receptor Message

1997 • 23 citations

Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells

1991 • 21 citations

Transdifferentiation of chicken embryonic cells into muscle cells by the 3' untranslated region of muscle tropomyosin.

1995 • 21 citations

Co-operation of the 5′ and 3′ untranslated regions of ornithine decarboxylase mRNA and inhibitory role of its 3′ untranslated region in regulating the translational efficiency of hybrid RNA species via cellular factor(s)

1997 • 19 citations

22 Translationally Coupled Degradation of mRNA in Eukaryotes

1996 • 17 citations

Enzyme-generated intracellular fluorescence for single-cell reporter gene analysis utilizingEscherichia coli ?-glucuronidase

1996 • 16 citations

Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.

1998 • 15 citations

Ratios between the abundance of messenger RNA and the corresponding protein of two growth-related genes, c-myc and vimentin, in leukemia blast cells.

1990 • 12 citations

Role of RNA Structure in RNA Editing

1998 • 3 citations

GUS as a Useful Reporter Gene in Animal Cells

1992 • 2 citations