Mechanisms of translational control in early development

Induction of germ cell formation by oskar

1992 • 643 citations

The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A

1988 • 625 citations

A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases

1988 • 602 citations

Nanos is the localized posterior determinant in Drosophila

1991 • 510 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos

1995 • 419 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

Translational regulation in development

1995 • 394 citations

RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos

1991 • 391 citations

THE BIOCHEMISTRY OF 3′-END CLEAVAGE AND POLYADENYLATION OF MESSENGER RNA PRECURSORS

1992 • 387 citations

RNA recognition and translational regulation by a homeodomain protein

1996 • 343 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.

1994 • 330 citations

Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities

1994 • 328 citations

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.

1994 • 320 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.

1996 • 287 citations

Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes.

1989 • 248 citations

Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse.

1994 • 243 citations

Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly

1995 • 243 citations

Transient translational silencing by reversible mRNA deadenylation

1992 • 239 citations

Isolation of caudal , a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage

1985 • 238 citations

Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region

1991 • 237 citations

Coordinate Initiation of Drosophila Development by Regulated Polyadenylation of Maternal Messenger RNAs

1994 • 236 citations

Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo

1994 • 231 citations

15 Translational Control of Developmental Decisions

2000 • 222 citations

Spatial and Temporal Controls Target pal-1 Blastomere-Specification Activity to a Single Blastomere Lineage in C. elegans Embryos

1996 • 219 citations

Localization of oskar RNA regulates oskar translation and requires Oskar protein

1995 • 208 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans

1993 • 191 citations

Sequence-specific adenylations and deadenylations accompany changes in the translation of maternal messenger RNA after fertilization of Spisula oocytes

1983 • 190 citations

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.

1994 • 187 citations

A conserved 90 nucleotide element mediates translational repression of nanos RNA

1996 • 174 citations

Tales of poly(A): a review

1990 • 171 citations

The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos

1992 • 165 citations

Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF.

1990 • 165 citations

aubergine enhances oskar translation in the Drosophila ovary

1996 • 164 citations

Translational control by poly(A) elongation during Xenopus development: differential repression and enhancement by a novel cytoplasmic polyadenylation element.

1992 • 156 citations

Maturation-specific polyadenylation and translational control: diversity of cytoplasmic polyadenylation elements, influence of poly(A) tail size, and formation of stable polyadenylation complexes.

1990 • 144 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers.

1993 • 127 citations

Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.

1994 • 125 citations

Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila.

1993 • 118 citations

Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.

1992 • 108 citations

Overexpression of poly(A) binding protein prevents maturation-specific deadenylation and translational inactivation in Xenopus oocytes.

1996 • 108 citations

Cytoplasmic 3′ poly(A) addition induces 5′ cap ribose methylation: implications for translational control of maternal mRNA.

1995 • 107 citations

Translational inactivation of ribosomal protein mRNAs during Xenopus oocyte maturation.

1988 • 106 citations

Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation.

1992 • 105 citations

Further analysis of cytoplasmic polyadenylation in Xenopus embryos and identification of embryonic cytoplasmic polyadenylation element-binding proteins.

1994 • 94 citations

A complex protein assembly catalyzes polyadenylation of mRNA precursors

1995 • 90 citations

Mutations that perturb poly(A)-dependent maternal mRNA activation block the initiation of development

1996 • 83 citations

Widespread changes in the translation and adenylation of maternal messenger RNAs following fertilization of Spisula oocytes

1987 • 83 citations

Polyadenylation of maternal mRNA during oocyte maturation: poly(A) addition in vitro requires a regulated RNA binding activity and a poly(A) polymerase.

1992 • 79 citations

Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region.

1990 • 70 citations

Multiple Sequence Elements and a Maternal mRNA Product Control cdk2 RNA Polyadenylation and Translation during Early Xenopus Development

1994 • 68 citations

Unmasking mRNA in Clam Oocytes: Role of Phosphorylation of a 3′ UTR Masking Element-Binding Protein at Fertilization

1996 • 50 citations

Multiple sequence elements and a maternal mRNA product control cdk2 RNA polyadenylation and translation during early Xenopus development.

1994 • 47 citations

Coupling transcription to translation: A novel site for the regulation of eukaryotic gene expression

1996 • 43 citations

The role of cap methylation in the translational activation of stored maternal histone mRNA in sea urchin embryos

1985 • 41 citations

Regulated polyadenylation of clam maternal mRNAs in vitro

1993 • 21 citations

Germ plasm formation and germ cell determination

1993 • 18 citations

17 Dynamics of Poly(A) Addition and Removal during Development

1996 • 17 citations