Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

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Fatty Acid Synthase and Cancer: New Application of an Old Pathway

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Increased lipogenesis in cancer cells: new players, novel targets

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Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity

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Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

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Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking

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Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!

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The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

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Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival

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Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.

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Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

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Inhibition of fatty acid synthase (FAS) suppressesHER2/neu(erbB-2) oncogene overexpression in cancer cells

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Glycolysis in cancer: A potential target for therapy

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Proteomic Study Reveals That Proteins Involved in Metabolic and Detoxification Pathways Are Highly Expressed in HER-2/neu-positive Breast Cancer

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Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.

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Fatty acid synthase: A metabolic oncogene in prostate cancer?

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Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.

1996 • 290 citations

Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival

1997 • 288 citations

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Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.

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RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.

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RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

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Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

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Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

1998 • 249 citations

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

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Selective activation of the fatty acid synthesis pathway in human prostate cancer

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Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

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Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

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Targets and mechanisms for the regulation of translation in malignant transformation

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Metabolic catastrophe as a means to cancer cell death

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Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.

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Energy Boost: The Warburg Effect Returns in a New Theory of Cancer

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Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.

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Hypoxia and adaptive landscapes in the evolution of carcinogenesis

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Epigallocatechin‐3‐gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

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Endoplasmic Reticulum Stress: A New Pathway to Induce Autophagy

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Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

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When translation meets transformation: the mTOR story

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Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells

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Activation of Fatty Acid Synthesis during Neoplastic Transformation: Role of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase

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Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

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Metabolic changes during carcinogenesis: Potential impact on invasiveness

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Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl-CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity

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Structure and function of animal fatty acid synthase

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Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2

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Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

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Pharmacological Inhibitors of Fatty Acid Synthase (FASN)-Catalyzed Endogenous Fatty Acid Biogenesis: A New Family of Anti-Cancer Agents?

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Green Tea Epigallocatechin Gallate: A Natural Inhibitor of Fatty-Acid Synthase

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Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

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Thymidylate synthase as an oncogene

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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

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Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

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Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells

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Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

2000 • 165 citations

The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

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Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

2004 • 164 citations

Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells

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Androgens Stimulate Lipogenic Gene Expression in Prostate Cancer Cells by Activation of the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein/Sterol Regulatory Element-Binding Protein Pathway

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Structure and molecular organization of mammalian fatty acid synthase

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Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1α

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Effects of nutrients and hormones on transcriptional and post‐transcriptional regulation of fatty acid synthase in rat liver

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Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c

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Living Without Oxygen

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‘Why do tumour cells glycolyse?’: From glycolysis through citrate to lipogenesis

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The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis

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A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2

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Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells¹

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The 17q23 Amplicon and Breast Cancer

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Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.

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Haptoglobin-Related Protein (Hpr) Epitopes in Breast Cancer as a Predictor of Recurrence of the Disease

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Fatty Acid Synthase (Fas) Predictive Strength in Poorly Differentiated Early Breast Carcinomas

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Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype

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Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma.

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Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

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BRCA1 Affects Lipid Synthesis through Its Interaction with Acetyl-CoA Carboxylase

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FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

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Going malignant: the hypoxia‐cancer connection in the prostate

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Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma☆

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A genomic explanation connecting “Mediterranean diet”, olive oil and cancer: Oleic acid, the main monounsaturated Fatty acid of olive oil, induces formation of inhibitory “PEA3 transcription factor-PEA3 DNA binding site” complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells

2006 • 117 citations

Targeting Fatty Acid Synthase in Breast and Endometrial Cancer: An Alternative to Selective Estrogen Receptor Modulators?

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Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

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Recent advances in insulin gene therapy for type 1 diabetes

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Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-κB

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The prognostic value of oncogenic antigen 519 (OA‐519) expression and proliferative activity detected by antibody MIB‐I in node‐negative breast cancer

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Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity

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Mediterranean Dietary Traditions for the Molecular Treatment of Human Cancer: Anti-Oncogenic Actions of the Main Olive Oils Monounsaturated Fatty Acid Oleic Acid (18:1n-9)

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Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats

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BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains

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Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast

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Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells

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Sterol Regulatory Element-Binding Protein-1 Participates in the Regulation of Fatty Acid Synthase Expression in Colorectal Neoplasia

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"Spot 14" Protein: A Metabolic Integrator in Normal and Neoplastic Cells

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In support of fatty acid synthase (FAS) as a metabolic oncogene: Extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells

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Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer

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Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation

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Inhibition of Tumor-associated Fatty Acid Synthase Hyperactivity Induces Synergistic Chemosensitization of HER-2/neu-Overexpressing Human Breast Cancer Cells to Docetaxel (taxotere)

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Fatty acid synthase: a novel target for antiglioma therapy

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Immunohistochemical Expression of Human Erythrocyte Glucose Transporter and Fatty Acid Synthase in Infiltrating Breast Carcinomas and Adjacent Typical/Atypical Hyperplastic or Normal Breast Tissue

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Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.

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S14 protein in breast cancer cells: Direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth

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Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells.

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Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma

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Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.

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Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?

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Targeting Fatty Acid Synthase: Potential for Therapeutic Intervention in Her-2/neu-Overexpressing Breast Cancer

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BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer

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The “Spot 14” gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism

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Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma.

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Expression of Fatty Acid Synthase Is Closely Linked to Proliferation and Stromal Decidualization in Cycling Endometrium

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Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model

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Key role of mitochondria in cerulenin-mediated apoptosis

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Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis

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Spot 14: A Marker of Aggressive Breast Cancer and a Potential Therapeutic Target

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Update on HER-2 as a target for cancer therapy: The ERBB2 promoter and its exploitation for cancer treatment

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Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

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Elevated Levels of Thymidylate Synthase Linked to Neoplastic Transformation of Mammalian Cells

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Expression of “Spot 14” (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker

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Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

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Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine®)-induced cytotoxicity and apoptotic cell death in human breast cancer cells

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Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism

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Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung

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Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism

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Orlistat: From Antiobesity Drug to Anticancer Agent in Her-2/neu (erbB-2)-Overexpressing Gastrointestinal Tumors?

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Acetyl-CoA carboxylase gene and breast cancer susceptibility

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The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival

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RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells

2005 • 29 citations

Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1? (HIF-1?)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene

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Evidence for a Putative Relationship Between Type 2 Diabetes and Neoplasia with Particular Reference to Breast Cancer: Role of Hormones, Growth Factors and Specific Receptors

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The Impact of Body Mass Index and Type 2 Diabetes on Breast Cancer: Current Therapeutic Measures of Prevention

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Haplotype-Based Analysis of Common Variation in theAcetyl-CoA Carboxylase αGene and Breast Cancer Risk: A Case-Control Study Nested within the European Prospective Investigation into Cancer and Nutrition

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Increased lipogenesis in steroid-responsive cancer cells: mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications.

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