RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

Lipid rafts and signal transduction

2000 • 6,079 citations

Fatty acid synthase, a proficient multifunctional enzyme

1989 • 801 citations

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

2000 • 770 citations

Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity

2004 • 570 citations

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

2000 • 527 citations

Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity

2004 • 444 citations

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

2000 • 362 citations

Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

2001 • 361 citations

Membrane raft microdomains mediate front–rear polarity in migrating cells

1999 • 316 citations

Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.

1997 • 315 citations

Lipotoxicity of the Pancreatic β-Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids

2001 • 305 citations

Fatty acid synthase: A metabolic oncogene in prostate cancer?

2003 • 293 citations

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.

1996 • 290 citations

Coordination of membrane phospholipid synthesis with the cell cycle.

1994 • 281 citations

Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.

1996 • 270 citations

RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.

2003 • 266 citations

Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

1997 • 253 citations

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

1998 • 249 citations

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

2003 • 248 citations

Selective activation of the fatty acid synthesis pathway in human prostate cancer

2000 • 240 citations

Cell surface polarization during yeast mating

2002 • 233 citations

Epigallocatechin‐3‐gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

2003 • 208 citations

Fatty-Acid Biosynthesis in Man, a Pathway of Minor Importance. Purification, Optimal Assay Conditions, and Organ Distribution of Fatty-Acid Synthase

1986 • 190 citations

Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl-CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity

2001 • 186 citations

Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism

1993 • 180 citations

Protein and lipid sorting from thetrans–Golgi network to the plasma membrane in polarized cells

1998 • 179 citations

Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

2005 • 170 citations

Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

2001 • 167 citations

The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung

2000 • 158 citations

Increased fatty acid synthase as a therapeutic target in androgen‐independent prostate cancer progression

2001 • 155 citations

Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells¹

2000 • 143 citations

Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach

2002 • 134 citations

Assay of short-chain acyl coenzyme a intermediates in tissue extracts by high-pressure liquid chromatography

1981 • 129 citations

Going malignant: the hypoxia‐cancer connection in the prostate

2002 • 118 citations

Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity

2005 • 109 citations

[9] Analysis of acyl-coenzyme A esters in biological samples

1988 • 88 citations

A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G ₂ /M phase of the cell cycle

2003 • 62 citations

Promoter-specific trans-activation and inhibition mediated by JunB.

1993 • 55 citations

[Biosynthesis of mevalonic acid, sterols and bile acids from acetyl-CoA and malonyl-CoA in the human liver].

1983 • 1 citations