Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

2005 • 2,774 citations

Metformin and reduced risk of cancer in diabetic patients

2005 • 2,278 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Insulin-like growth factors and neoplasia

2004 • 1,452 citations

Very high risk of cancer in familial Peutz–Jeghers syndrome

2000 • 1,386 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

2006 • 910 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 859 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 609 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

The blooming of the French lilac

2001 • 355 citations

Role of Lkb1 , the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis

2002 • 150 citations

Down-regulation of Insulin Receptor by Antibodies against the Type I Insulin-Like Growth Factor Receptor: Implications for Anti–Insulin-Like Growth Factor Therapy in Breast Cancer

2006 • 116 citations

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase

2004 • 51 citations

Influence of Caloric Intake on Experimental Carcinogenesis: A Review

1986 • 51 citations

Insulin resistance, estimated by serum C-peptide level, is associated with reduced event-free survival for postmenopausal women in NCIC CTG MA.14 adjuvant breast cancer trial

2006 • 51 citations

Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target

2004 • 31 citations