BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

2004 • 3,444 citations

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

2003 • 2,170 citations

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

2006 • 1,296 citations

Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

2006 • 1,038 citations

AMP-activated protein kinase signaling in metabolic regulation

2006 • 1,007 citations

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

2003 • 989 citations

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

2000 • 770 citations

Physical Activity and Cancer Prevention: Etiologic Evidence and Biological Mechanisms

2002 • 704 citations

Increased lipogenesis in cancer cells: new players, novel targets

2006 • 577 citations

Physical Activity and the Risk of Breast Cancer

1997 • 576 citations

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

2005 • 477 citations

AMPK, the metabolic syndrome and cancer

2005 • 415 citations

Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival

2006 • 328 citations

Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.

1997 • 315 citations

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

2004 • 236 citations

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

2004 • 224 citations

Energy restriction and the risk of spontaneous mammary tumors in mice: A meta‐analysis

2003 • 147 citations

Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype

2005 • 127 citations

BRCA1 Affects Lipid Synthesis through Its Interaction with Acetyl-CoA Carboxylase

2005 • 123 citations

BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains

2002 • 99 citations

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells

2006 • 93 citations

Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis

2006 • 51 citations

Acetyl-CoA carboxylase gene and breast cancer susceptibility

2004 • 31 citations

ACCA Phosphopeptide Recognition by the BRCT Repeats of BRCA1

2006 • 29 citations

Evidence for a Putative Relationship Between Type 2 Diabetes and Neoplasia with Particular Reference to Breast Cancer: Role of Hormones, Growth Factors and Specific Receptors

2004 • 26 citations

The Impact of Body Mass Index and Type 2 Diabetes on Breast Cancer: Current Therapeutic Measures of Prevention

2004 • 19 citations

Haplotype-Based Analysis of Common Variation in theAcetyl-CoA Carboxylase αGene and Breast Cancer Risk: A Case-Control Study Nested within the European Prospective Investigation into Cancer and Nutrition

2007 • 11 citations