The 17q23 Amplicon and Breast Cancer

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

2001 • 655 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

2001 • 574 citations

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1997 • 529 citations

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

2002 • 426 citations

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

2000 • 416 citations

Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.

1997 • 409 citations

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

2000 • 367 citations

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

1997 • 362 citations

Molecular cytogenetics of primary breast cancer by CGH

1998 • 362 citations

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

2002 • 353 citations

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

1999 • 334 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer.

1995 • 302 citations

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

2000 • 296 citations

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

2000 • 284 citations

Detecting Activation of Ribosomal Protein S6 Kinase by Complementary DNA and Tissue Microarray Analysis

2000 • 280 citations

Assessment of Genetic Changes in Hepatocellular Carcinoma by Comparative Genomic Hybridization Analysis

1999 • 275 citations

Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung.

1997 • 261 citations

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer

2001 • 259 citations

Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia

2000 • 248 citations

Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas.

1995 • 230 citations

Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization

1995 • 226 citations

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

1994 • 225 citations

Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization

1994 • 211 citations

Expression of Chick Tbx-2, Tbx-3, and Tbx-5 Genes during Early Heart Development: Evidence for BMP2 Induction of Tbx2

2000 • 208 citations

Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.

2000 • 197 citations

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

1985 • 195 citations

Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas

1997 • 193 citations

Gain of chromosome 17 is the most frequent abnormality detected in neuroblastoma by comparative genomic hybridization.

1997 • 185 citations

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

1998 • 173 citations

Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridization.

1996 • 171 citations

Genetic alterations in lobular breast cancer by comparative genomic hybridization

1997 • 159 citations

The T-box Repressors TBX2 and TBX3Specifically Regulate the Tumor Suppressor Genep14 via a Variant T-site in the Initiator

2002 • 156 citations

Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification.

1997 • 155 citations

Molecular cytogenetic fingerprinting of esophageal squamous cell carcinoma by comparative genomic hybridization reveals a consistent pattern of chromosomal alterations

1999 • 151 citations

The p21-Activated Kinase PAK Is Negatively Regulated by POPX1 and POPX2, a Pair of Serine/Threonine Phosphatases of the PP2C Family

2002 • 144 citations

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

1998 • 127 citations

FGF Signaling Regulates Expression of Tbx2, Erm, Pea3, and Pax3 in the Early Nasal Region

2002 • 118 citations

Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomic hybridization.

1995 • 113 citations

Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer.

1999 • 99 citations

Increased copy number at 17q22-q24 by CGH in breast cancer is due to high-level amplification of two separate regions

1997 • 97 citations

17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes.

2000 • 94 citations

Cellular function of p70^S6K: A role in regulating cell motility

2000 • 89 citations

Differences in genetic alterations between primary lobular and ductal breast cancers detected by comparative genomic hybridization

2001 • 88 citations

Murine Tbx2 contains domains that activate and repress gene transcription

2002 • 72 citations

Follicle-Stimulating Hormone Activates Mitogen-Activated Protein Kinase in Preneoplastic and Neoplastic Ovarian Surface Epithelial Cells

2002 • 72 citations

Genetic analysis of 53 lymph node-negative breast carcinomas by CGH and relation to clinical, pathological, morphometric, and DNA cytometric prognostic factors

1998 • 72 citations

BRCA1 and BRCA2 have a limited role in familial prostate cancer.

2000 • 67 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in patients with endometrioid carcinoma

2000 • 62 citations

Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis

2001 • 57 citations

PS6KAmplification Characterizes a Small Subset of Anaplastic Meningiomas

2001 • 51 citations

Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors.

2001 • 51 citations

A New Role for the p85-Phosphatidylinositol 3-Kinase Regulatory Subunit Linking FRAP to p70 S6 Kinase Activation

2002 • 46 citations

Genetic Imbalances in Precursor Lesions of Endometrial Cancer Detected by Comparative Genomic Hybridization

2000 • 45 citations

Conserved expression control and shared activity between cognate T‐box genes Tbx2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development

2002 • 40 citations

Detection of Gains and Losses in 18 Meningiomas by Comparative Genomic Hybridization

1998 • 40 citations

Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina.

2001 • 37 citations

Overexpressed Genes/ESTs and Characterization of Distinct Amplicons on 17823 in Breast Cancer Cells

2001 • 25 citations

Role of MLK3-mediated Activation of p70 S6 Kinase in Rac1 Transformation

2002 • 25 citations

Characterization of Chromosomal Breakpoints in an ALL Patient using Cross-Species Color Banding

2000 • 4 citations