Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

2007 • 1,809 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

2007 • 1,418 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

2007 • 1,381 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

The IL-23/IL-17 axis in inflammation

2006 • 1,004 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

2007 • 686 citations

IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

2007 • 550 citations

Therapeutic benefit of blocking interleukin‐6 activity with an anti–interleukin‐6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled, dose‐escalation trial

2002 • 531 citations

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

2008 • 509 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Transcriptional regulation of Th17 cell differentiation

2007 • 469 citations

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

IL-17–dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants

2007 • 393 citations

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

2008 • 355 citations

Development in Motion: Helper T Cells at Work

2007 • 314 citations

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation

2006 • 295 citations

Interleukin-23 (IL-23)-IL-17 Cytokine Axis in Murine Pneumocystis carinii Infection

2007 • 248 citations

Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D3

2000 • 240 citations

Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

2006 • 204 citations

Tocilizumab: The first interleukin-6-receptor inhibitor

2008 • 192 citations

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

2006 • 148 citations

Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

1995 • 145 citations

Review: Immune cells and mediators of inflammatory arthritis

2008 • 120 citations

Transforming growth factor beta downregulates interleukin-1 (IL-1)- induced IL-6 production by human monocytes

1990 • 77 citations

Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

2006 • 65 citations

Tocilizumab: Blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders

2006 • 64 citations

TGF-β: How Tolerant Can It Be?

2003 • 40 citations

Good for Goose, but Not for Gander: IL-2 Interferes with Th17 Differentiation

2007 • 39 citations

Inflammation and TGFβ1: Lessons from the TGFβ1 null mouse

1997 • 36 citations

Using Single‐Gene Deletions to Identify Checkpoints in the Progression of Systemic Autoimmunity

2003 • 32 citations

Antisense Targeting Protein Kinase A Type I as a Drug for Integrated Strategies of Cancer Therapy

2003 • 25 citations

Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells.

1993 • 25 citations