TGF-β: How Tolerant Can It Be?

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

How cells read TGF-β signals

2000 • 1,843 citations

Regulatory T Cells

2000 • 1,827 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

T Cell Anergy

2003 • 1,418 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Type 1 T regulatory cells

2001 • 829 citations

Infectious immunological tolerance.

1971 • 811 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

Two major Smad pathways in TGF‐β superfamily signalling

2002 • 647 citations

Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells

2002 • 632 citations

Infectious Tolerance

2002 • 614 citations

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

2003 • 582 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Certified Professionals

2001 • 533 citations

Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts

1981 • 511 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

2002 • 501 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive Milieu

2001 • 414 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift

2000 • 365 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

TGF-β: from latent to active

1999 • 329 citations

CD3-specific antibody-induced active tolerance: from bench to bedside

2003 • 305 citations

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

2002 • 267 citations

Human allograft acceptance is associated with immune regulation

2000 • 261 citations

CD4+ regulatory T cells

2001 • 241 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

The mucosal milieu creates tolerogenic dendritic cells and TR1 and TH3 regulatory cells

2001 • 209 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)

2003 • 177 citations

TGF-β signaling from receptors to the nucleus

1999 • 141 citations

Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.

1999 • 138 citations

Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model.

1998 • 134 citations

Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells

2000 • 124 citations

Positive selection of thymocytes bearing αβ T cell receptors

1997 • 124 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

TGF-β Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar

2000 • 104 citations

Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-β1

1998 • 99 citations

Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes

2002 • 98 citations

The ever-increasing complexity of TGF-β signaling

2002 • 81 citations

TGF-β: Receptors, Signaling Pathways and Autoimmunity

2001 • 77 citations

Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice

2002 • 71 citations

Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation

2000 • 70 citations

Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis.

1998 • 66 citations

An overview of regulatory T cells

2001 • 64 citations

TGF-β: 20 years and counting

1999 • 53 citations

Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice.

1997 • 38 citations

Plasminogen/Plasminogen Activator and Growth Factor Activation

2007 • 27 citations