TOR in the immune system

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

2016 • 4,824 citations

mTOR: from growth signal integration to cancer, diabetes and ageing

2010 • 3,777 citations

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

2009 • 3,397 citations

Follicular Helper CD4 T Cells (T_FH)

2011 • 2,505 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

2011 • 1,834 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

2011 • 1,540 citations

Plasticity of CD4+ T Cell Lineage Differentiation

2009 • 1,476 citations

mTOR regulates memory CD8 T-cell differentiation

2009 • 1,473 citations

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

2009 • 1,425 citations

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 • 1,172 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

2009 • 1,068 citations

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

2011 • 1,023 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

2008 • 741 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Activation of mTORC2 by Association with the Ribosome

2011 • 625 citations

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

2009 • 619 citations

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

2008 • 616 citations

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

2009 • 614 citations

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

2010 • 604 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

2010 • 478 citations

CD8⁺ T‐cell memory in tumor immunology and immunotherapy

2006 • 472 citations

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

2010 • 470 citations

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8 ⁺ memory T cell subsets

2004 • 466 citations

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

2010 • 458 citations

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

2009 • 456 citations

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

2010 • 442 citations

Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance

2007 • 416 citations

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

2007 • 415 citations

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

2008 • 383 citations

Origins of CD4+ effector and central memory T cells

2011 • 376 citations

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

2008 • 375 citations

Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

2003 • 373 citations

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

2010 • 341 citations

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

2011 • 327 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

2010 • 296 citations

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

2008 • 265 citations

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses

2010 • 263 citations

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

2011 • 256 citations

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

2010 • 220 citations

Regulatory T cells in obesity: the leptin connection

2010 • 173 citations

The role of mTOR in memory CD8⁺ T‐cell differentiation

2010 • 166 citations

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

2010 • 163 citations

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

2011 • 147 citations

A longer and healthier life with TOR down-regulation: genetics and drugs

2011 • 122 citations

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

2008 • 119 citations

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

2010 • 116 citations

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

2010 • 113 citations

TOR signaling never gets old: Aging, longevity and TORC1 activity

2010 • 109 citations

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS

2010 • 107 citations

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

2011 • 106 citations

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

2011 • 101 citations

mTOR signalling and metabolic regulation of T cell differentiation

2010 • 85 citations

Phosphoinositide 3‐kinase and the mammalian target of rapamycin pathways control T cell migration

2010 • 81 citations

Mammalian models of extended healthy lifespan

2010 • 73 citations

Hot topics in aging research: protein translation and TOR signaling, 2010

2010 • 69 citations

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

2010 • 68 citations

Direct activation of mTOR in B lymphocytes confers impairment in B‐cell maturation andloss of marginal zone B cells

2011 • 66 citations

Human CD34-Derived Myeloid Dendritic Cell Development Requires Intact Phosphatidylinositol 3-Kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling

2010 • 50 citations

The influence of mTOR on T helper cell differentiation and dendritic cell function

2011 • 31 citations