Nuclear Factor of Activated T Cells Is Associated with a Mast Cell Interleukin 4 Transcription Complex

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

1994 • 123 citations

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

1993 • 103 citations

New concepts about the mast cell

1994 • 94 citations

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

1992 • 83 citations

Activation and Functions of CD4⁺ T‐Cell Subsets

1991 • 79 citations

A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer.

1992 • 78 citations

Cyclosporine and FK506 inhibition of murine mast cell cytokine production.

1992 • 73 citations

Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12.

1992 • 68 citations

T cell-specific negative regulation of transcription of the human cytokine IL-4.

1992 • 67 citations

The interleukin-4 family of lymphokines

1992 • 67 citations

The Ca²⁺/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene

1994 • 62 citations

Molecular dissection of the mouse interleukin-4 promoter.

1993 • 59 citations

A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.

1993 • 47 citations

An activation-responsive element in the murine IL-4 gene is the site of an inducible DNA-protein interaction.

1993 • 29 citations

Characterization of the constitutive and inducible components of a T cell IL-4 activation responsive element.

1995 • 21 citations

Characterization of NF(P), the Nuclear Factor That Interacts with the Regulatory P Sequence (5′-CGAAAATTTCC-3′) of the Human Interleukin-4 Gene: Relationship to NF-κB and NF-AT

1994 • 20 citations