T Cell Development

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENT

1999 • 245 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Expression of the CD4 gene requires a Myb transcription factor.

1992 • 127 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

Elf-1 binds to a critical element in a second CD4 enhancer.

1994 • 92 citations

Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

1992 • 83 citations

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1997 • 75 citations

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

2001 • 67 citations

Hierarchical Interactions of Control Elements Determine CD8α Gene Expression in Subsets of Thymocytes and Peripheral T Cells

1998 • 66 citations

Identification and characterization of a human CD4 silencer

1996 • 64 citations

A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.

1997 • 63 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

Genomic organization of the human LAG-3/CD4 locus

1997 • 46 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Identification of a Candidate Regulatory Region in the HumanCD8Gene Complex by Colocalization of DNase I Hypersensitive Sites and Matrix Attachment Regions Which Bind SATB1 and GATA-3

2002 • 33 citations

Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development.

1998 • 23 citations

Appropriate developmental expression of human CD8 beta in transgenic mice.

1997 • 22 citations

CD8 Coreceptor Extinction in Signaled CD4⁺CD8⁺ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

2000 • 21 citations

Distinct Stage-Specific cis-Active Transcriptional Mechanisms Control Expression of T Cell Coreceptor CD8α at Double- and Single-Positive Stages of Thymic Development

1998 • 19 citations

Post-transcriptional regulation associated with control of human CD8A expression of CD4 + T cells

1996 • 13 citations