In Activated Mast Cells, IL-1 Up-Regulates the Production of Several Th2-Related Cytokines Including IL-9

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Allergy: Principles and Practice.

1991 • 1,717 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Mast cells as a source of multifunctional cytokines

1990 • 708 citations

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1998 • 568 citations

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

1993 • 561 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness

1998 • 448 citations

Mast cells as sentinels of innate immunity

1999 • 394 citations

The Importance of Th2 Cytokines in Protective Immunity to Nematodes

1992 • 352 citations

Activated mast cells produce interleukin 13.

1995 • 320 citations

Mast cell growth‐enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9)

1990 • 302 citations

Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity.

1988 • 297 citations

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.

1994 • 284 citations

Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness.

1996 • 263 citations

Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.

1988 • 244 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Interleukin 9: A candidate gene for asthma

1997 • 236 citations

Mast cells: function and contents

1994 • 221 citations

125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells.

1987 • 214 citations

Evidence for Linkage Between Asthma/Atopy in Childhood and Chromosome 5q31-q33 in a Japanese Population

1997 • 187 citations

Interleukin-9 Promotes Allergen-Induced Eosinophilic Inflammation and Airway Hyperresponsiveness in Transgenic Mice

1998 • 186 citations

Interleukin‐9 is involved in host protective immunity to intestinal nematode infection

1997 • 185 citations

Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity.

1980 • 176 citations

Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).

1989 • 173 citations

The mast cell in health and disease

1990 • 170 citations

Interleukin-9 Enhances Resistance to the Intestinal NematodeTrichuris muris

1998 • 149 citations

Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases.

1993 • 140 citations

Th2 cells mediate IL-4-dependent local tissue inflammation.

1993 • 140 citations

Intraepithelial Infiltration by Mast Cells with Both Connective Tissue-Type and Mucosal-Type Characteristics in Gut, Trachea, and Kidneys of IL-9 Transgenic Mice

1998 • 137 citations

Human mast cell cytokines

1996 • 132 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

Interleukin 9 and its Receptor: An Overview of Structure and Function

1998 • 129 citations

B cell growth and differentiation activity of interleukin‐hp1 and related murine plasmacytoma growth factors. synergy with interleukin 1

1988 • 125 citations

Tcgfiii/p40 is produced by naive murine cd4+ t cells but is not a general t cell growth factor*

1989 • 115 citations

Mast‐cell—leukocyte cytokine cascades in allergic inflammation

1995 • 96 citations

Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4.

1989 • 93 citations

Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.

1988 • 75 citations

IL-1 serves as a secondary signal for IL-9 expression.

1991 • 71 citations

Stem cell factor and Interleukin-4 induce murine bone marrow cells to develop into mast cells with connective tissue type characteristics in vitro

1999 • 65 citations

Immunolocalization of cytokines to mast cells in normal and allergic conjunctiva

1997 • 65 citations

A cascade of cytokines is responsible for IL-9 expression in human T cells. Involvement of IL-2, IL-4, and IL-10.

1995 • 61 citations

Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.

1989 • 59 citations

Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors

1990 • 52 citations

IL-4 renders mast cells functionally responsive to endothelin-1.

1995 • 50 citations

B‐cell chronic lymphocytic leukaemia cells express and release transforming growth factor‐β

1992 • 49 citations

Characterization of hemopoietic cell populations from human cord blood expressing c-kit.

1993 • 47 citations

Purification of MEA, a mast cell growth-enhancing activity, to apparent homogeneity and its partial amino acid sequencing.

1990 • 39 citations

Post-transcriptional Stabilization by Interleukin-1β of Interleukin-6 mRNA Induced by c-kit Ligand and Interleukin-10 in Mouse Bone Marrow-derived Mast Cells

1996 • 38 citations

Partial purification of a mast cell growth-enhancing activity and its separation from IL-3 and IL-4.

1989 • 37 citations

The effects of stem cell factor on the ultrastructure of Fc epsilon RI+ cells developing in IL-3-dependent murine bone marrow-derived cell cultures.

1993 • 35 citations

Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages

1996 • 25 citations

IL-1 alpha induces granulocyte-macrophage colony-stimulating factor gene expression in murine B lymphocyte cell lines via mRNA stabilization.

1991 • 20 citations

Kinetics of interleukin‐6 production after experimental infection of mice with Schistosoma mansoni

1996 • 16 citations

Cytokine secretion by human mast cells

1995 • 14 citations

Mast cells enhance the antibody-mediated injury of skin basement membrane in mice.

1992 • 10 citations

Deleted Work

1955 • 0 citations