Granulocyte Colony-stimulating Factor Induces egr-1Up-regulation through Interaction of Serum Response Element-binding Proteins

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Granulocyte colony-stimulating factor and its receptor

1991 • 975 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Granulocyte colony-stimulating factor and its receptor

1991 • 797 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Specificity within the ets Family of Transcription Factors

1998 • 343 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Molecular analysis of the granulocyte colony-stimulating factor receptor

1996 • 291 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.

1992 • 237 citations

A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

1993 • 223 citations

Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.

1990 • 218 citations

Functional serum response elements upstream of the growth factor-inducible gene zif268.

1989 • 180 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

Early Growth Response-1-dependent Apoptosis Is Mediated by p53

1997 • 172 citations

MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo

1999 • 170 citations

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes

1996 • 156 citations

Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.

1994 • 144 citations

Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition

2000 • 143 citations

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.

1992 • 132 citations

Role of primary response genes in generating cellular responses to growth factors

1992 • 124 citations

Characterization of Messenger Ribonucleoprotein and Messenger RNA from KB Cells

1972 • 119 citations

Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors.

1994 • 113 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements

1997 • 107 citations

Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation.

1991 • 98 citations

Extracellular signals, transcriptional responses and cellular specificity

1989 • 98 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter.

1994 • 96 citations

The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle.

1994 • 95 citations

Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells.

1989 • 93 citations

The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts.

1991 • 92 citations

Activation of the Sap-1a Transcription Factor by the c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase

1997 • 86 citations

The Immediate-Early Gene Product Egr-1 Regulates the Human Interleukin-2 Receptor β-Chain Promoter through Noncanonical Egr and Sp1 Binding Sites

1997 • 86 citations

The Zinc Finger Transcription Factor Egr-1 Activates Macrophage Differentiation in M1 Myeloblastic Leukemia Cells

1998 • 84 citations

Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells.

1989 • 81 citations

A Ternary Complex Factor-Dependent Mechanism Mediates Induction of egr-1 through Selective Serum Response Elements following Antigen Receptor Cross-Linking in B Lymphocytes

1995 • 72 citations

Raf and Fibroblast Growth Factor Phosphorylate Elk1 and Activate the Serum Response Element of the Immediate Early Genepip92 by Mitogen-Activated Protein Kinase-Independent as Well as -Dependent Signaling Pathways

1998 • 68 citations

The Transcription Factor Early Growth Response 1 (Egr-1) Advances Differentiation of Pre-B and Immature B Cells

1998 • 64 citations

Ternary Complex Factors Elk-1 and Sap-1a Mediate Growth Hormone-Induced Transcription of Egr-1 (Early Growth Response Factor-1) in 3T3-F442A Preadipocytes

1999 • 64 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

A Potential Role for Elf-1 in Terminal Transferase Gene Regulation

1996 • 59 citations

Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor.

1994 • 53 citations

Elk-1 Can Recruit SRF to Form a Ternary Complex Upon the Serum Response Element

1996 • 53 citations

Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome.

1988 • 41 citations

Role of Egr-1 Gene Expression in B Cell Receptor-induced Apoptosis in an Immature B Cell Lymphoma

1997 • 37 citations

Transcriptional activation of the immediate early gene pip92 by serum growth factors requires both Ets and CArG-like elements.

1994 • 36 citations

v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements

1992 • 34 citations

HTLV-I and HTLV-II tax trans-activate the human EGR-1 promoter through different cis-acting sequences.

1992 • 33 citations

Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid.

1993 • 31 citations

Hemopoietic growth factors and their interactions with specific receptors

1987 • 30 citations

LLC-PK1 Cell Growth Is Repressed by WT1 Inhibition of G-protein αi−2 Protooncogene Transcription

1995 • 22 citations

Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(.beta.-D-arabinofuranosyl)cytosine

1993 • 19 citations

Response of murine IL3-sensitive cell lines to cytokines of human and murine origin.

1989 • 19 citations

Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.

1994 • 18 citations

The immediate early gene response to a differentiative stimulus is disrupted by the v-abl and v-ras oncogenes.

1992 • 18 citations

Characterization of a cell-type-restricted negative regulatory activity of the human granulocyte-macrophage colony-stimulating factor gene.

1994 • 13 citations