Calcium-induced phosphorylation of ETS1 inhibits its specific DNA binding activity.
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References (57)
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The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.
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The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.
1990 • 189 citations
Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.
1993 • 180 citations
Evolutionarily conserved Ets family members display distinct DNA binding specificities.
1992 • 175 citations
Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression
1992 • 147 citations
Complementary patterns of expression of c-ets 1, c-myb and c-myc in the blood-forming system of the chick embryo
1989 • 147 citations
A novel modulator domain of Ets transcription factors.
1992 • 147 citations
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1990 • 146 citations
Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes.
1994 • 141 citations
DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism.
1992 • 137 citations
Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded protein.
1988 • 136 citations
Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein
1992 • 124 citations
Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins.
1988 • 118 citations
Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.
1986 • 114 citations
Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins.
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1990 • 101 citations
Definition of an Ets1 Protein Domain Required for Nuclear Localization in Cells and DNA-Binding Activity In Vitro
1989 • 98 citations
Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling.
1993 • 93 citations
High-affinity DNA-protein interactions of the cellular ETS1 protein: the determination of the ETS binding motif.
1991 • 78 citations
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
1993 • 73 citations
The c-ets-1 protein is chromatin associated and binds to DNA in vitro.
1989 • 70 citations
pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.
1992 • 61 citations
Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1.
1991 • 55 citations
A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74
1993 • 55 citations
Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.
1990 • 53 citations
Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene.
1988 • 43 citations
Requirement of an ETS-binding element for transcription of the human lck type I promoter.
1993 • 32 citations
Identification of a Ets1 variant protein unaffected in its chromatin and in vitro DNA binding capacities by T cell antigen receptor triggering and intracellular calcium rises.
1990 • 31 citations
Cloning and expression of chicken p54c-ets cDNAs: the first p54c-ets coding exon is located into the 40.0 kbp genomic domain unrelated to v-ets.
1988 • 29 citations
The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins.
1994 • 28 citations
c-Ets-1 protein is hyperphosphorylated during mitosis.
1993 • 18 citations