Signal Transduction by Tumor Necrosis Factor Mediated by JNK Protein Kinases

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Two TNF receptors

1992 • 1,048 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

1993 • 341 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture.

1993 • 224 citations

Tumor Necrosis Factors: Gene Structure and Biological Activities

1986 • 215 citations

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

1993 • 211 citations

Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.

1992 • 197 citations

Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.

1990 • 189 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

1967 • 177 citations

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

1993 • 168 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

1992 • 152 citations

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

1993 • 146 citations

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

1992 • 138 citations

Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

1992 • 138 citations

Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.

1993 • 128 citations

Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.

1993 • 125 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor.

1992 • 117 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells

1993 • 116 citations

Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.

1992 • 109 citations

Tumor necrosis factor (TNF) up-regulates the expression of p75 but not p55 TNF receptors, and both receptors mediate, independently of each other, up-regulation of transforming growth factor alpha and epidermal growth factor receptor mRNA.

1993 • 102 citations

Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.

1993 • 82 citations

Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.

1991 • 78 citations

Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization.

1988 • 75 citations

Interleukin 1 induction of the c-jun promoter.

1993 • 73 citations

Herbimycin A blocks IL‐1‐induced NF‐κB DNA‐binding activity in lymphoid cell lines

1992 • 71 citations

Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.

1990 • 69 citations

Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein.

1993 • 58 citations

Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling.

1993 • 57 citations

Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells.

1990 • 53 citations

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis.

1992 • 42 citations

A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase

1994 • 35 citations

Interleukin-1-inducible tumor growth arrest is characterized by activation of cell type-specific “early” gene expression programs.

1992 • 33 citations

Cytotoxicity by tumor necrosis factor is mediated by both p55 and p70 receptors

1993 • 28 citations

Identification of an inducible 85-kDa nuclear protein kinase.

1993 • 21 citations