Protein serine/threonine phosphatases

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

1995 • 850 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

1993 • 662 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site

1995 • 428 citations

Crystal Structure of the Catalytic Subunit of Human Protein Phosphatase 1 and its Complex with Tungstate

1995 • 418 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

The protein phosphatases involved in cellular regulation. Identification of the inhibitor-2 phosphatases in rabbit skeletal muscle

1984 • 330 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

1991 • 279 citations

Identification of a New Family of Protein Phosphatase 2A Regulatory Subunits

1995 • 219 citations

Purification and Characterization of Two Potent Heat-Stable Protein Inhibitors of Protein Phosphatase 2A from Bovine Kidney

1995 • 214 citations

Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis

1994 • 181 citations

Conservation analysis and structure prediction of the protein serine/threonine phosphatases

1994 • 177 citations

Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.

1993 • 170 citations

The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions. Identification of calcineurin as a Zn and Fe metalloenzyme.

1984 • 160 citations

Multiple Structural Elements Define the Specificity of Recombinant Human Inhibitor-1 as a Protein Phosphatase-1 Inhibitor^,

1996 • 155 citations

Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein

1995 • 136 citations

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

1988 • 115 citations

Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.

1995 • 115 citations

Conserved sequence pattern in a wide variety of phosphoesterases

1994 • 114 citations

Purple acid phosphatase: a diiron enzyme that catalyzes a direct phospho group transfer to water

1993 • 106 citations

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1994 • 105 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

The protein phosphatases involved in cellular regulation

1985 • 94 citations

Cyclophilin Residues That Affect Noncompetitive Inhibition of the Protein Serine Phosphatase Activity of Calcineurin by the Cyclophilin.cntdot.Cyclosporin A Complex

1994 • 74 citations

A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.

1994 • 71 citations

Tyrosine-272 Is Involved in the Inhibition of Protein Phosphatase-1 by Multiple Toxins

1996 • 65 citations

Flicking the switches: phosphorylation of serine/threonine protein phosphatases

1995 • 62 citations

Mechanistic aspects of the low-molecular-weight phosphatase activity of the calmodulin-activated phosphatase, calcineurin.

1986 • 54 citations

Evidence That Calcineurin Accommodates an Active Site Binuclear Metal Center

1995 • 54 citations

Interaction of FKBP12-FK506 with Calcineurin A at the B Subunit-binding Domain

1995 • 53 citations

Isotope effects on the mechanism of calcineurin catalysis: kinetic solvent isotope and isotope exchange studies

1994 • 48 citations

Control and activity of type-1 serine/threonine protein phosphatase during the cell cycle

1995 • 28 citations

The role of calcineurin in immune system responses

1995 • 19 citations

Calcineurin inhibits desensitization of cloned rat 5-HT1C receptors

1993 • 19 citations

A medicinal chemistry evaluation of the autoinhibitory domain of calcineurin

1995 • 4 citations