Mast cells as modulators of T‐cell responses

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2002 • 1,644 citations

Mast cells

1997 • 1,636 citations

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

2006 • 1,520 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

Mast cells in the development of adaptive immune responses

2005 • 1,252 citations

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

2005 • 1,216 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

1978 • 846 citations

Mast-cell responses to pathogens

2004 • 833 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Mast cells are essential intermediaries in regulatory T-cell tolerance

2006 • 742 citations

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

2001 • 650 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

1978 • 634 citations

Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1.

1991 • 626 citations

Mast Cell-Deficient W-sash c-kit Mutant KitW-sh/W-sh Mice as a Model for Investigating Mast Cell Biology in Vivo

2005 • 573 citations

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

2006 • 562 citations

Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

1985 • 503 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice

2001 • 437 citations

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

2000 • 427 citations

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

2003 • 416 citations

Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice

2000 • 400 citations

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

2006 • 390 citations

Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

2000 • 384 citations

Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues

2003 • 361 citations

The diverse potential effector and immunoregulatory roles of mast cells in allergic disease

2000 • 361 citations

Fundamental Immunology

2004 • 359 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

Substance P selectively activates TNF-alpha gene expression in murine mast cells.

1993 • 333 citations

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

2003 • 312 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 312 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 292 citations

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice

2001 • 284 citations

Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4

2003 • 282 citations

Mast cells can promote the development of multiple features of chronic asthma in mice

2006 • 270 citations

Mast Cell-Associated TNF Promotes Dendritic Cell Migration

2006 • 262 citations

Intracerebral Recruitment and Maturation of Dendritic Cells in the Onset and Progression of Experimental Autoimmune Encephalomyelitis

2000 • 251 citations

Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology

2006 • 243 citations

Human Mast Cells Release Metalloproteinase-9 on Contact with Activated T Cells: Juxtacrine Regulation by TNF-α

2001 • 225 citations

Mast cell–T cell interactions

1999 • 224 citations

Complement Peptides C3a- and C5a-Induced Mediator Release from Dissociated Human Skin Mast Cells

1994 • 221 citations

Long-term in vitro culture of murine mast cells. I. Description of a growth factor-dependent culture technique.

1981 • 208 citations

Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.

1996 • 206 citations

CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

2005 • 204 citations

Mast cells in innate immunity

2004 • 197 citations

Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

1995 • 195 citations

IgE Enhances Parasite Clearance and Regulates Mast Cell Responses in Mice Infected with Trichinella spiralis

2004 • 187 citations

Immune Sensitization in the Skin Is Enhanced by Antigen-Independent Effects of IgE

2004 • 183 citations

Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells.

1995 • 182 citations

Antigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma.

1993 • 176 citations

Mast cell activation and migration to lymph nodes during induction of an immune response in mice.

1998 • 173 citations

Dendritic Cells in Multiple Sclerosis Lesions: Maturation Stage, Myelin Uptake, and Interaction With Proliferating T Cells

2006 • 166 citations

The mast cells of the mammalian central nervous system

1974 • 162 citations

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

2004 • 159 citations

Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.

1997 • 152 citations

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells

2005 • 148 citations

IL-12– and IL-23–induced T helper cell subsets

2005 • 139 citations

C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils

2002 • 138 citations

Specificity, magnitude, and kinetics of MOG‐specific CD8⁺ T cell responses during experimental autoimmune encephalomyelitis

2004 • 137 citations

Generation of mucosal mast cells is stimulated in vitro by factors derived from T cells of helminth-infected rats

1982 • 135 citations

Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease Course

2003 • 126 citations

Brain mast cell degranulation regulates blood-brain barrier

1996 • 121 citations

Mast Cells Have a Pivotal Role in TNF-Independent Lymph Node Hypertrophy and the Mobilization of Langerhans Cells in Response to Bacterial Peptidoglycan

2006 • 119 citations

Multiple sclerosis: a battle between destruction and repair

2006 • 119 citations

Mast cells in rat thalamus: Nuclear localization, sex difference and left-right asymmetry

1984 • 115 citations

Myelin-Specific Cd8 T Cells in the Pathogenesis of Experimental Allergic Encephalitis and Multiple Sclerosis

2001 • 114 citations

Effector Mechanisms of Immunity to Schistosomes and Their Regulation

1982 • 112 citations

Interactions of mast cells with the nervous system ?Recent advances

1992 • 112 citations

Dendritic Cell Modulation by Mast Cells Controls the Th1/Th2 Balance in Responding T Cells

2006 • 110 citations

Induction and enhancement of Fc(epsilon)RI-dependent mast cell degranulation following coculture with activated T cells: dependency on ICAM-1- and leukocyte function-associated antigen (LFA)-1-mediated heterotypic aggregation.

1998 • 109 citations

The mast cells of the multiple sclerosis brain

1996 • 107 citations

The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation

1988 • 106 citations

Rat Peritoneal Mast Cells Present Antigen to a PPD-Specific T Cell Line

1994 • 103 citations

The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8+ T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness

2006 • 101 citations

Mast cells in experimental allergic encephalomyelitis: characterization, distribution in the CNS and in vitro activation by myelin basic protein and neuropeptides

1994 • 98 citations

Activated T lymphocytes induce degranulation and cytokine production by human mast cells following cell-to-cell contact

1998 • 98 citations

Histamine and prostaglandin E₂ up‐regulate the production of Th2‐attracting chemokines (CCL17 and CCL22) and down‐regulate IFN‐γ‐induced CXCL10 production by immature human dendritic cells

2006 • 96 citations

The role of mast cells in the elicitation of experimental allergic encephalomyelitis.

1989 • 92 citations

Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE

2006 • 92 citations

CNS dendritic cells: Critical participants in CNS inflammation?

2006 • 92 citations

Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

1983 • 86 citations

Cutting Edge: Histamine Inhibits IFN-α Release from Plasmacytoid Dendritic Cells

2003 • 84 citations

Induction and Enhancement of FcεRI-Dependent Mast Cell Degranulation Following Coculture with Activated T Cells: Dependency on ICAM-1- and Leukocyte Function-Associated Antigen (LFA)-1-Mediated Heterotypic Aggregation

1998 • 83 citations

Mast cells are potent regulators of endothelial cell adhesion molecule ICAM‐1 and VCAM‐1 expression

1995 • 83 citations

Mast Cell Cytokine and Chemokine Responses to Bacterial and Viral Infection

2003 • 83 citations

Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis

2005 • 80 citations

Regulation of early peritoneal neutrophil migration by macrophage inflammatory protein-2 and mast cells in experimental peritonitis

1999 • 79 citations

The Mast Cell: A Versatile Effector Cell for a Challenging World

1997 • 76 citations

Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination

1993 • 72 citations

Presentation of Soluble Antigens by Mast Cells: Upregulation by Interleukin-4 and Granulocyte/Macrophage Colony-Stimulating Factor and Downregulation by Interferon-γ

1995 • 72 citations

The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo

2006 • 71 citations

Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis

1996 • 64 citations

An Analysis of Mast Cell Frequency in the Rodent Nervous System: Numbers Vary between Different Strains and Can Be Reconstituted in Mast Cell-Deficient Mice

1991 • 57 citations

Interferon-gamma-like molecule induces Ia antigens on cultured mast cell progenitors.

1982 • 57 citations

Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon-gamma.

1984 • 55 citations

Mast cell‐derived tumour necrosis factor‐α mediates macrophage inflammatory protein‐2‐induced recruitment of neutrophils in mice

2005 • 52 citations

Regulation of mast cell activation by complement-derived peptides

2004 • 51 citations

Ueber das Vorkommen der sogenannten „Mastzellen” bei pathologischen Veränderungen des Gehirns

1890 • 47 citations

IFN-γ-Stimulated Enhancement of MHC Class II Antigen Expression by the Human Mast Cell Line HMC-1

1996 • 47 citations

Mast cell proteases liberate stable encephalitogenic fragments from intact myelin

1991 • 44 citations

Mast Cells Induce T-Cell Adhesion to Human Fibroblasts by Regulating Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion with Expression

1995 • 42 citations

IL-4 mRNA transcription is induced in mouse bone marrow-derived mast cells through an MHC class II-dependent signaling pathway

1998 • 38 citations

Presence and Distribution of Nervous System‐Associated Mast Cells That May Modulate Experimental Autoimmune Encephalomyelitis

1988 • 30 citations

Modification of the clinical and histopathologic expression of experimental allergic encephalomyelitis by the vasoactive amine antagonist cyproheptadine

1984 • 22 citations

Type I Interferons Attenuate T Cell Activating Functions of Human Mast Cells by Decreasing TNF-α Production and OX40 Ligand Expression While Increasing IL-10 Production

2006 • 18 citations

The influence of cinanserin and selected pharmacologic agents on experimental allergic encephalomyelitis (EAE).

1971 • 12 citations

Regulation of mast cell survival and activation by monomeric IgE

2004 • 2 citations