Mast Cells Have a Pivotal Role in TNF-Independent Lymph Node Hypertrophy and the Mobilization of Langerhans Cells in Response to Bacterial Peptidoglycan

Peptidoglycan types of bacterial cell walls and their taxonomic implications

1972 • 3,772 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

2003 • 2,325 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

2003 • 1,651 citations

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

2003 • 1,265 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Mast cells in the development of adaptive immune responses

2005 • 1,252 citations

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

2005 • 1,216 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

5 Analysis of the Chemical Composition and Primary Structure of Murein

1985 • 710 citations

Mast cells as a source of multifunctional cytokines

1990 • 708 citations

Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2

2003 • 661 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

1985 • 503 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 496 citations

Mast Cell-Derived Exosomes Induce Phenotypic and Functional Maturation of Dendritic Cells and Elicit Specific Immune Responses In Vivo

2003 • 413 citations

Peptidoglycan Recognition Proteins

2001 • 389 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 384 citations

Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

2000 • 384 citations

Peptidoglycan recognition proteins (PGRPs)

2003 • 373 citations

Protective Roles of Mast Cells Against Enterobacterial Infection Are Mediated by Toll-Like Receptor 4

2001 • 373 citations

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.

1991 • 369 citations

Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells

2003 • 351 citations

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

2003 • 312 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 312 citations

Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha.

1991 • 298 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 292 citations

Toll‐like receptor 2 (TLR2) and TLR4 differentially activate human mast cells

2003 • 292 citations

Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells.

1979 • 264 citations

Mast Cell-Associated TNF Promotes Dendritic Cell Migration

2006 • 262 citations

C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway.

1996 • 250 citations

Mast cells enhance T cell activation: Importance of mast cell-derived TNF

2005 • 249 citations

Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells

2001 • 248 citations

The Role of Complement in B Cell Activation and Tolerance

1999 • 235 citations

The role of complement in inflammation and adaptive immunity

2001 • 229 citations

Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis

2000 • 213 citations

Long-term in vitro culture of murine mast cells. I. Description of a growth factor-dependent culture technique.

1981 • 208 citations

Toll-like receptor 4-mediated activation of murine mast cells

2001 • 204 citations

Mast cells in innate immunity

2004 • 197 citations

Immunologic Release of β-Hexosaminidase and β-Glucuronidase from Purified Rat Serosal Mast Cells

1979 • 189 citations

Immune Sensitization in the Skin Is Enhanced by Antigen-Independent Effects of IgE

2004 • 183 citations

Visualization and Characterization of Migratory Langerhans Cells in Murine Skin and Lymph Nodes by Antibodies Against Langerin/CD207

2003 • 177 citations

Histamine Induces CD86 Expression and Chemokine Production by Human Immature Dendritic Cells

2001 • 161 citations

Human Mannose-binding Lectin and l-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement

2004 • 161 citations

IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo

2004 • 131 citations

The Immunological Activities of Bacterial Peptidoglycans

1980 • 131 citations

Activation of the alternate complement pathway by peptidoglycan from streptococcal cell wall

1978 • 129 citations

Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

1998 • 116 citations

Induced expression of mRNA for IL-5, IL-6, TNF-alpha, MIP-2 and IFN-gamma in immunologically activated rat peritoneal mast cells: inhibition by dexamethasone and cyclosporin A.

1995 • 95 citations

Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.

1996 • 89 citations

Pseudomonas aeruginosaActivates Human Mast Cells to Induce Neutrophil Transendothelial Migration Via Mast Cell-Derived IL-1α and β

2002 • 87 citations

Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells

1996 • 79 citations

Mast Cells Induce Autoantibody-Mediated Vasculitis Syndrome Through Tumor Necrosis Factor Production Upon Triggering Fcγ Receptors

1999 • 70 citations

The Streptococcal Exotoxin Streptolysin O Activates Mast Cells To Produce Tumor Necrosis Factor Alpha by p38 Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Pathways

2003 • 63 citations

The role of Staphylococcus aureus cell-wall peptidoglycan, teichoic acid and protein A in the processes of complement activation and opsonization.

1979 • 63 citations

Mast cell‐derived tumour necrosis factor‐α mediates macrophage inflammatory protein‐2‐induced recruitment of neutrophils in mice

2005 • 52 citations

Undiminished immunologic tolerance to contact sensitivity in mast cell-deficient W/Wv and Sl/Sld mice.

1985 • 46 citations

Enzyme immunometric assay for leukotriene C4

1994 • 18 citations

Production of TNF-α by Murine Bone Marrow Derived Mast Cells Activated by the Bacterial Fimbrial Protein, FimH

1999 • 11 citations