Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.

1992 • 519 citations

Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region

1985 • 502 citations

Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state

1994 • 499 citations

Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J _κ

1994 • 462 citations

trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

1986 • 363 citations

The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.

1994 • 352 citations

The Human Herpesviruses

1993 • 301 citations

Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes

1992 • 258 citations

A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection

1989 • 254 citations

Effect of regional DNA methylation on gene expression.

1985 • 232 citations

A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1

1995 • 220 citations

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.

1993 • 187 citations

trans Activation of an Epstein-Barr Viral Transcriptional Enhancer by the Epstein-Barr Viral Nuclear Antigen 1

1986 • 176 citations

Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa

1995 • 167 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

1994 • 151 citations

5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael

1989 • 149 citations

Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer.

1994 • 147 citations

The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.

1994 • 138 citations

Transcriptional Activation of the Epstein-Barr Virus Latency C Promoter after 5-Azacytidine Treatment: Evidence that Demethylation at a Single CpG Site Is Crucial

1995 • 125 citations

Inactive chromatin spreads from a focus of methylation.

1993 • 124 citations

Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA

1996 • 113 citations

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines

1996 • 101 citations

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated

1983 • 87 citations

CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease

1996 • 76 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

Enhancement of reporter gene de novo methylation by DNA fragments from the alpha-fetoprotein control region.

1994 • 69 citations

Spreading of DNA methylation across integrated foreign (adenovirus type 12) genomes in mammalian cells

1991 • 68 citations

Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.

1992 • 63 citations

Complete DNA methylation does not prevent polyoma and simian virus 40 virus early gene expression.

1983 • 63 citations

Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes

1997 • 59 citations

The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence

1995 • 46 citations

Ubiquitous and Tenacious Methylation of the CpG Site in Codon 248 of the p53 Gene May Explain Its Frequent Appearance as a Mutational Hot Spot in Human Cancer

1994 • 43 citations

Inactive Chromatin Spreads from a Focus of Methylation

1993 • 37 citations

Molecular genetic analysis of Epstein-Barr virus Cp promoter function

1996 • 32 citations

Improved recombinant PCR mutagenesis procedure that uses alkaline-denatured plasmid template.

1995 • 28 citations

Viral and Cellular Factors Influence the Activity of the Epstein-Barr Virus BCR2 and BWR1 Promoters in Cells of Different Phenotype

1993 • 27 citations

Efficient EBV Superinfection of Group I Burkitt's Lymphoma Cells Distinguishes Requirements for Expression of the Cp Viral Promoter and Can Activate the EBV Productive Cycle

1995 • 17 citations

Characterization of Epstein–Barr Virus Recombinants with Deletions of theBamHI C Promoter

1996 • 17 citations

Pharmacologic Activation of Expression of Immunodominant Viral Antigens: A New Strategy for the Treatment of Epstein-Barr-Virus-Associated Malignancies

1995 • 11 citations

Transcription inhibition of SV40 by in vitro DNA methylation

1990 • 9 citations