Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virus BamHI W promoter in Burkitt lymphoma lines

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2001 • 133,517 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

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1980 • 1,430 citations

Expression of Epstein–Barr Virus Transformation–Associated Genes in Tissues of Patients with EBV Lymphoproliferative Disease

1989 • 803 citations

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1968 • 781 citations

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

1987 • 735 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.

1988 • 330 citations

Sensitivity of Epstein‐Barr virus (EBV) producer and non‐producer human lymphoblastoid cell lines to superinfection with EB‐virus

1972 • 300 citations

Establishment in continuous culture of a new type of lymphocyte from a “burkitt‐like” malignant lymphoma (line d.g.‐75)

1977 • 286 citations

EBV gene expression in an NPC-related tumour.

1989 • 248 citations

Effect of regional DNA methylation on gene expression.

1985 • 232 citations

Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site.

1986 • 230 citations

Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype.

1987 • 209 citations

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.

1990 • 196 citations

Epstein-Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line

1980 • 175 citations

Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.

1991 • 153 citations

5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael

1989 • 149 citations

The Role of Methylation in the Phenotype-dependent Modulation of Epstein-Barr Nuclear Antigen 2 and Latent Membrane Protein Genes in Cells Latently Infected with Epstein-Barr Virus

1989 • 125 citations

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes.

1989 • 122 citations

A promoter for the highly spliced EBNA family of RNAs of Epstein-Barr virus

1987 • 122 citations

Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

1985 • 115 citations

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes.

1991 • 109 citations

Epstein-Barr virus mRNAs produced by alternative splicing

1986 • 100 citations

Activation of the epstein‐barr virus genome by 5‐aza‐cytidine in latently infected human lymphoid lines

1981 • 97 citations

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

1988 • 96 citations

An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide.

1986 • 88 citations

Variable expression of latent membrane protein in nasopharyngeal carcinoma can be related to methylation status of the Epstein-Barr virus BNLF-1 5'-flanking region

1991 • 78 citations

Host cell phenotype-dependent methylation patterns of Epstein--Barr virus DNA

1991 • 60 citations

Understanding the molecular mechanism by which methylation influences gene expression

1989 • 59 citations

The 5′ flanking region of the gene for the Epstein-Barr virus-encoded nuclear antigen 2 contains a cell type specificcis-acting regulatory element that activates transcription in transfected B-cells

1988 • 54 citations

RNA encoded by the IR1-U2 region of Epstein-Barr virus DNA in latently infected, growth-transformed cells

1983 • 47 citations

Identification of Sequences in Epstein-Barr Virus DNA Required for the Expression of the Second Epstein-Barr Virus-determined Nuclear Antigen in COS-1 Cells

1987 • 36 citations

The Coupling Between Enhancer Activity and Hypomethylation of κ Immunoglobulin Genes is Developmentally Regulated

1988 • 36 citations

CpG methylation of viral DNA in EBV‐associated tumours

1990 • 32 citations

Complexities in Gene Regulation by Promoter Methylation

1989 • 25 citations