Control of B Cell Production by the Adaptor Protein Lnk

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Identification of the Earliest B Lineage Stage in Mouse Bone Marrow

1996 • 395 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

The complexity of signaling pathways activated by the BCR

1997 • 333 citations

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

1999 • 321 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1996 • 249 citations

Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons

1998 • 224 citations

Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis.

1995 • 216 citations

B cell development: signal transduction by antigen receptors and their surrogates

1999 • 186 citations

Identification of SH2-Bβ as a Substrate of the Tyrosine Kinase JAK2 Involved in Growth Hormone Signaling

1997 • 175 citations

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase.

1995 • 158 citations

The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions

1995 • 157 citations

B-cell development: a comparison between mouse and man

1998 • 154 citations

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

1997 • 129 citations

SH2 and SH3‐containing adaptor proteins: redundant or independent mediators of intracellular signal transduction

1996 • 123 citations

Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.

1995 • 122 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lymphadenopathy.

1991 • 117 citations

The Role of mel-18, a Mammalian Polycomb Group Gene, during IL-7–Dependent Proliferation of Lymphocyte Precursors

1997 • 112 citations

Surrogate Light Chain in B Cell Development

1996 • 110 citations

Cloning and Characterization of Human Lnk, an Adaptor Protein with Pleckstrin Homology and Src Homology 2 Domains that Can Inhibit T Cell Activation

2000 • 110 citations

Identification of the APS Protein as a Novel Insulin Receptor Substrate

1999 • 99 citations

SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

1998 • 90 citations

SH2-B Is Required for Nerve Growth Factor-induced Neuronal Differentiation

1999 • 88 citations

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

1999 • 81 citations

Characterization of Lnk

1997 • 77 citations

Acquisition of surface IgD fails to protect from tolerance-induction. Both surface IgM- and surface IgD-mediated signals induce apoptosis of immature murine B lymphocytes.

1996 • 72 citations

PSM, an Insulin-Dependent, Pro-Rich, PH, SH2 Domain Containing Partner of the Insulin Receptor

1997 • 69 citations

Platelet-derived Growth Factor (PDGF) Stimulates the Association of SH2-Bβ with PDGF Receptor and Phosphorylation of SH2-Bβ

1998 • 65 citations

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

1999 • 64 citations

The yeast tribrid system : genetic detection of trans-phosphorylated ITAM-SH2-interactions

1995 • 63 citations

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

1999 • 60 citations

B-cell development

1981 • 58 citations

Loss of c-kit Accompanies B-Lineage Commitment and Acquisition of CD45R by Most Murine B-Lymphocyte Precursors

1999 • 49 citations

Molecular Cloning of the Mouse APS as a Member of the Lnk Family Adaptor Proteins

2000 • 38 citations

Signaling checkpoints during the development of T lymphocytes

1998 • 37 citations

An IFN-γ-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus

1994 • 34 citations

IgM-Mediated B Cell Apoptosis

1995 • 14 citations

Signal transduction pathways regulating the development of αβ T cells

1998 • 6 citations