APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

The insulin signalling system and the IRS proteins

1997 • 582 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

The IRS-signalling system during insulin and cytokine action

1997 • 280 citations

Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons

1998 • 224 citations

A Novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes

1998 • 216 citations

From receptor to transporter: insulin signalling to glucose transport

1997 • 211 citations

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

1995 • 163 citations

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase.

1995 • 158 citations

The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions

1995 • 157 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 139 citations

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

1997 • 129 citations

Human GRB-IRβ/GRB10

1997 • 116 citations

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

1991 • 112 citations

Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases

1998 • 111 citations

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

1997 • 101 citations

Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus

1996 • 100 citations

Identification of the APS Protein as a Novel Insulin Receptor Substrate

1999 • 99 citations

SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

1998 • 90 citations

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

1991 • 82 citations

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

1999 • 81 citations

Insulin-like Growth Factor-I Receptor and Insulin Receptor Association with a Src Homology-2 Domain-containing Putative Adapter

1998 • 72 citations

PSM, an Insulin-Dependent, Pro-Rich, PH, SH2 Domain Containing Partner of the Insulin Receptor

1997 • 69 citations

Interaction of MAD2 with the Carboxyl Terminus of the Insulin Receptor but Not with the IGFIR EVIDENCE FOR RELEASE FROM THE INSULIN RECEPTOR AFTER ACTIVATION

1997 • 45 citations

Site-Directed Mutagenesis and Yeast Two-Hybrid Studies of the Insulin and Insulin-Like Growth Factor-1 Receptors: The Src Homology-2 Domain-Containing Protein hGrb10 Binds to the Autophosphorylated Tyrosine Residues in the Kinase Domain of the Insulin Receptor

1997 • 43 citations

Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

1998 • 29 citations

Refinement of Vectors for Use in the Yeast Two-Hybrid System

1996 • 23 citations

The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases.

1994 • 21 citations