Progress in bioinformatics and the importance of being earnest

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DNA sequencing with chain-terminating inhibitors

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Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

KEGG: Kyoto Encyclopedia of Genes and Genomes

1999 • 30,001 citations

KEGG: Kyoto Encyclopedia of Genes and Genomes

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Initial sequencing and analysis of the human genome

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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

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The Pfam protein families database.

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A general method applicable to the search for similarities in the amino acid sequence of two proteins

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Identification of common molecular subsequences

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A new method for sequencing DNA.

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Toward principles for the design of ontologies used for knowledge sharing?

1995 • 7,651 citations

The Genome Sequence of Drosophila melanogaster

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Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

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Atlas of protein sequence and structure

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Life with 6000 Genes

1996 • 4,125 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

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The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

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A Protein Sequenator

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Evolution and Tinkering

1977 • 2,509 citations

The Minimal Gene Complement of Mycoplasma genitalium

1995 • 2,499 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Distinguishing Homologous from Analogous Proteins

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

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Introduction to expert systems

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Method for Determination of the Amino Acid Sequence in Peptides.

1950 • 1,360 citations

The Pfam Protein Families Database

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The PROSITE database, its status in 1999

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The EMBL Nucleotide Sequence Database

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Readings in Knowledge Representation

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The InterPro database, an integrated documentation resource for protein families, domains and functional sites

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Life itself: a comprehensive inquiry into the nature, origin, and fabrication of life

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G-protein-coupled receptors and signaling networks: emerging paradigms

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Representation and Understanding

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The disulphide bonds of insulin

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WHAT'S IN A LINK

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Protein function in the post-genomic era

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Some Studies in Machine Learning Using the Game of Checkers. II—Recent Progress

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ON THE EPISTEMOLOGICAL STATUS OF SEMANTIC NETWORKS**Prepared in part at Bolt Beranek and Newman Inc. under contracts sponsored by the Defense Advance Research Projects Agency and the Office of Naval Research. The views and conclusions stated are those of the author and should not be interpreted as necessarily representing the official policies, either express or implied, of the Defense Advanced Research Projects Agency or the U.S. Government.

1979 • 652 citations

Homology

2000 • 610 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

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What IS-A Is and Isn't: An Analysis of Taxonomic Links in Semantic Networks

1983 • 574 citations

An introduction to expert systems

1989 • 535 citations

Dendral and meta-dendral: Their applications dimension

1978 • 455 citations

The Role of the Genome Project in Determining Gene Function: Insights from Model Organisms

1996 • 450 citations

Associative Networks: The Representation and Use of Knowledge by Computers

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The Sequence of the Amino Acid Residues in Performic Acid-oxidized Ribonuclease

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WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction

2000 • 398 citations

ProDom and ProDom-CG: tools for protein domain analysis and whole genome comparisons

2000 • 372 citations

Errors in genome annotation

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Increased coverage of protein families with the Blocks Database servers

2000 • 336 citations

Structure-based assignment of the biochemical function of a hypothetical protein: A test case of structural genomics

1998 • 325 citations

DNA sequencing using capillary array electrophoresis

1992 • 305 citations

Cyc: a mid-term report

1990 • 281 citations

Dendral and meta-dendral

1978 • 249 citations

The PIR-International Protein Sequence Database

1999 • 240 citations

The superfamily of heptahelical receptors

2000 • 228 citations

PRINTS-S: the database formerly known as PRINTS

2000 • 223 citations

Genome Annotation Assessment in Drosophila melanogaster

2000 • 206 citations

Topology and life: In search of general mathematical principles in biology and sociology

1954 • 204 citations

"I Lied about the Trees" Or, Defaults and Definitions in Knowledge Representation

1985 • 201 citations

Systems biology: The reincarnation of systems theory applied in biology?

2001 • 188 citations

An ontology for biological function based on molecular interactions

2000 • 186 citations

Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement and operon disruption.

1998 • 181 citations

Can sequence determine function?

2000 • 153 citations

Artificial Intelligence

1992 • 139 citations

Orthologs, paralogs and genome comparisons

1999 • 136 citations

Artificial intelligence and molecular biology

1992 • 135 citations

Sequence analysis primer

1992 • 123 citations

Progress in protein structure prediction: Assessment of CASP3

1999 • 121 citations

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle: Table 1.

2000 • 121 citations

Improving the sensitivity of the sequence profile method

1994 • 118 citations

Combination of threading potentials and sequence profiles improves fold recognition 1 1Edited by B. Honig

2000 • 116 citations

The EMBL nucleotide sequence database

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A draft annotation and overview of the human genome

2001 • 106 citations

Go hunting in sequence databases but watch out for the traps

1996 • 105 citations

MAGPIE: automated genome interpretation

1996 • 105 citations

The use of aggregation in causal simulation

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Annotating eukaryote genomes

2000 • 99 citations

Artificial Intelligence and Molecular Biology

1994 • 97 citations

The emergence of complexity: science coming of age or science growing old?

2001 • 94 citations

Approaches to knowledge representation — An introduction

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Protein folding: Predicting predicting

1994 • 75 citations

DBcat: a catalog of biological databases

1999 • 75 citations

The path not taken

2001 • 67 citations

The Babel of Bioinformatics

2000 • 59 citations

Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!

2000 • 43 citations

Sisyphus and prediction of protein structure

1997 • 43 citations

Bioinformatics in the Information Age

2000 • 35 citations

DBcat: a catalog of 500 biological databases

2000 • 35 citations

Evidence-based illiteracy: time to rescue “the literature”

2000 • 29 citations

SELEX and the evolution of genomes

1997 • 29 citations

A qualitative biochemistry and its application to the regulation of the tryptophan operon

1993 • 28 citations

Late-Night Thoughts on the Sequence Annotation Problem

1998 • 28 citations

Evolution, language and analogy in functional genomics

2001 • 27 citations

AI Growing Up: The Changes and Opportunities

1998 • 26 citations

Ontological foundations for biology knowledge models.

1996 • 24 citations

Which craft is best in bioinformatics?

2001 • 19 citations

Unreliability of the Chou-Fasman parameters in predicting protein secondary structure

1998 • 19 citations

Nucleic Acid Sequence Bank

1980 • 17 citations

Sequence analysis primer

1992 • 16 citations

Whither genomics?

2000 • 15 citations

From fold recognition to homology modeling: an analysis of protein modeling challenges at different levels of prediction complexity

2000 • 11 citations

Evidence-based illiteracy: time to rescue “the literature”

2000 • 9 citations

Technical comment to “Database verification studies of SWISS-PROT and GenBank” by Karp et al.

2001 • 9 citations

Representing scientific experiments: implications for ontology design and knowledge sharing

1998 • 8 citations

Nucleic acid sequence bank

1980 • 8 citations

DEPARTMENT OF ERROR

2000 • 1 citations

Converting Data to Knowledge

2000 • 1 citations

Pharmacogenetics initiative galvanizes public and private sectors

2001 • 1 citations

Deleted Work

1955 • 0 citations