Orthologs, paralogs and genome comparisons

Basic local alignment search tool

1990 • 87,358 citations

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Life with 6000 Genes

1996 • 4,125 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Cases in which Parsimony or Compatibility Methods will be Positively Misleading

1978 • 2,881 citations

Cases in which Parsimony or Compatibility Methods Will be Positively Misleading

1978 • 2,193 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Phylogenetic Classification and the Universal Tree

1999 • 1,872 citations

Molecular evidence for an ancient duplication of the entire yeast genome

1997 • 1,786 citations

Distinguishing Homologous from Analogous Proteins

1970 • 1,512 citations

The Causes of Evolution

1966 • 1,352 citations

Bacterial gene transfer by natural genetic transformation in the environment

1994 • 1,253 citations

The hydrogen hypothesis for the first eukaryote

1998 • 1,240 citations

Origin and evolution of the elements

1993 • 1,159 citations

The universal ancestor

1998 • 1,033 citations

Evolutionary relationship of archaebacteria, eubacteria, and eukaryotes inferred from phylogenetic trees of duplicated genes.

1989 • 906 citations

The Material Basis of Evolution

1941 • 865 citations

The Material Basis of Evolution

1915 • 847 citations

Vertebrate genome evolution and the zebrafish gene map

1998 • 823 citations

Evolution of the vacuolar H+-ATPase: implications for the origin of eukaryotes.

1989 • 776 citations

Selfish Operons: Horizontal Transfer May Drive the Evolution of Gene Clusters

1996 • 686 citations

Performance of Phylogenetic Methods in Simulation

1995 • 594 citations

Origins of Prokaryotes, Eukaryotes, Mitochondria, and Chloroplasts

1978 • 589 citations

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

1998 • 532 citations

Evolution of the Vertebrate Genome as Reflected in Paralogous Chromosomal Regions in Man and the House Mouse

1993 • 475 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches

1999 • 446 citations

Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications.

1995 • 378 citations

Convergent evolution: the need to be explicit

1994 • 367 citations

Protein sequence similarity searches using patterns as seeds

1998 • 329 citations

Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species

1999 • 320 citations

Comparison of archaeal and bacterial genomes: computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaea

1997 • 316 citations

Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities 1 1Edited by G. Von Heijne

1998 • 297 citations

The cDNA sequence of the 69-kDa subunit of the carrot vacuolar H+-ATPase. Homology to the beta-chain of F0F1-ATPases.

1988 • 277 citations

A diverse superfamily of enzymes with ATP‐dependent carboxylate—amine/thiol ligase activity

1997 • 275 citations

The root of the universal tree and the origin of eukaryotes based on elongation factor phylogeny.

1996 • 274 citations

Evolution of HSP70 gene and its implications regarding relationships between archaebacteria, eubacteria, and eukaryotes

1993 • 272 citations

The evolution of the Calvin cycle from prokaryotic to eukaryotic chromosomes: a case study of functional redundancy in ancient pathways through endosymbiosis

1997 • 253 citations

Molecular Evolution by Wen-Hsiung Li. Published by Sinauer Associates, Sunderland, MA, USA. ISBN: 0-87893-463-4 (cloth).

1997 • 252 citations

Horizontal transfer of ATPase genes — the tree of life becomes a net of life

1993 • 244 citations

Phylogenetic characterization of novel transport protein families revealed by genome analyses

1999 • 233 citations

Comparable Rates of Gene Loss and Functional Divergence After Genome Duplications Early in Vertebrate Evolution

1997 • 229 citations

Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution

1998 • 209 citations

Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits

1991 • 199 citations

Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes

1982 • 194 citations

Distribution of Protein Folds in the Three Superkingdoms of Life

1999 • 183 citations

The TATA-Binding Protein: a General Transcription Factor in Eukaryotes and Archaebacteria

1994 • 183 citations

Phylogenies of Developmentally Important Proteins Do Not Support the Hypothesis of Two Rounds of Genome Duplication Early in Vertebrate History

1999 • 176 citations

Organization of the Prokaryotic Genome

1999 • 170 citations

Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements

1998 • 170 citations

The Evolution of the Type I Interferons1

1998 • 168 citations

Eukaryote genome duplication - where's the evidence?

1998 • 163 citations

Beyond complete genomes: from sequence to structure and function

1998 • 162 citations

Was the nucleus the first endosymbiont?

1994 • 162 citations

REDUNDANT GENES

1975 • 151 citations

Evolution of glutamate dehydrogenase genes: Evidence for two paralogous protein families and unusual branching patterns of the archaebacteria in the universal tree of life

1993 • 144 citations

The Estimation of the Number and the Length Distribution of Gene Conversion Tracts From Population DNA Sequence Data

1997 • 143 citations

Gene Duplication and Gene Conversion in the Caenorhabditis elegans Genome

1999 • 143 citations

How long did it take for life to begin and evolve to cyanobacteria?

1994 • 133 citations

Cloning of the HSP70 gene from Halobacterium marismortui: relatedness of archaebacterial HSP70 to its eubacterial homologs and a model for the evolution of the HSP70 gene

1992 • 132 citations

Extent of genomic rearrangement after genome duplication in yeast

1998 • 127 citations

Evidence for Ancient Tetraploidy and Conservation of Linkage Groups in Mammalian Chromosomes

1972 • 118 citations

The Root of the Universal Tree of Life Inferred from Anciently Duplicated Genes Encoding Components of the Protein-Targeting Machinery

1998 • 112 citations

Protein evolution viewed through Escherichia coli Protein sequences: Introducing the notion of a structural segment of homology, the module

1997 • 109 citations

The nature of the last universal ancestor and the root of the tree of life, still open questions

1992 • 108 citations

A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli.

1995 • 102 citations

Archaea: narrowing the gap between prokaryotes and eukaryotes.

1995 • 98 citations

Promoter Structures and Differential Responses to Viral and Nonviral Inducers of Chicken Type I Interferon Genes

1998 • 93 citations

The Prokaryote-to-Eukaryote Transition Reflected in the Evolution of the V/F/A-ATPase Catalytic and Proteolipid Subunits

1998 • 88 citations

Transcription factor IID in the Archaea: sequences in the Thermococcus celer genome would encode a product closely related to the TATA-binding protein of eukaryotes.

1994 • 86 citations

Evolution of proton pumping ATPases: Rooting the tree of life

1992 • 83 citations

Evolution of microbial life

1996 • 82 citations

Fine-resolution mapping of spontaneous and double-strand break-induced gene conversion tracts in Saccharomyces cerevisiae reveals reversible mitotic conversion polarity.

1994 • 82 citations

Evolution and isoforms of V-ATPase subunits

1992 • 81 citations

Evolution of microbial life

1997 • 79 citations

The origin of the eukaryotic cell.

1984 • 77 citations

The early evolution of cellular life

1995 • 75 citations

Phylogenetic analysis of sequences from diverse bacteria with homology to the Escherichia coli rho gene

1994 • 70 citations

Early evolutionary relationships among known life forms inferred from elongation factor EF-2/EF-G sequences: Phylogenetic coherence and structure of the archaeal domain

1992 • 62 citations

Widespread protein sequence similarities: origins of Escherichia coli genes

1995 • 50 citations

Glutamine synthetase gene evolution in bacteria.

1995 • 47 citations

Gene products of Escherichia coli: sequence comparisons and common ancestries.

1995 • 42 citations

Fine-Resolution Analysis of Products of Intrachromosomal Homeologous Recombination in Mammalian Cells

1997 • 38 citations

Evidence of independent gene duplications during the evolution of archaeal and eukaryotic family B DNA polymerases

1998 • 34 citations

Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins

1996 • 32 citations

Convergent evolution of amino acid usage in archaebacterial and eubacterial lineages adapted to high salt

1995 • 32 citations

Panning for Genes—A Visual Strategy for Identifying Novel Gene Orthologs and Paralogs

1999 • 27 citations

Gene duplications and horizontal gene transfer during early evolution

1996 • 25 citations

The Origin and Evolution of the Cell

1993 • 23 citations

Vertebrate Genome Evolution—The Decade Ahead

1997 • 17 citations

MICROBIAL DIVERSITY: Domains and Kingdoms

1996 • 14 citations