Which craft is best in bioinformatics?

Basic local alignment search tool

1990 • 87,358 citations

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

The Pfam protein families database.

2002 • 14,298 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Evolution and Tinkering

1977 • 2,509 citations

The PROSITE database, its status in 1997

1997 • 1,783 citations

Distinguishing Homologous from Analogous Proteins

1970 • 1,512 citations

The Pfam Protein Families Database

2000 • 1,235 citations

The PROSITE database, its status in 1999

1999 • 1,109 citations

The InterPro database, an integrated documentation resource for protein families, domains and functional sites

2001 • 1,049 citations

Protein function in the post-genomic era

2000 • 721 citations

The pacific symposium on biocomputing

1998 • 688 citations

Homology

2000 • 610 citations

The Role of the Genome Project in Determining Gene Function: Insights from Model Organisms

1996 • 450 citations

Errors in genome annotation

1999 • 371 citations

Increased coverage of protein families with the Blocks Database servers

2000 • 336 citations

Who's your neighbor? New computational approaches for functional genomics

2000 • 328 citations

Structure-based assignment of the biochemical function of a hypothetical protein: A test case of structural genomics

1998 • 325 citations

Cyc: a mid-term report

1990 • 281 citations

PRINTS-S: the database formerly known as PRINTS

2000 • 223 citations

Genome Annotation Assessment in Drosophila melanogaster

2000 • 206 citations

An ontology for biological function based on molecular interactions

2000 • 186 citations

Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement and operon disruption.

1998 • 181 citations

Can sequence determine function?

2000 • 153 citations

Orthologs, paralogs and genome comparisons

1999 • 136 citations

Progress in protein structure prediction: Assessment of CASP3

1999 • 121 citations

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle: Table 1.

2000 • 121 citations

Combination of threading potentials and sequence profiles improves fold recognition 1 1Edited by B. Honig

2000 • 116 citations

Go hunting in sequence databases but watch out for the traps

1996 • 105 citations

Annotating eukaryote genomes

2000 • 99 citations

The Babel of Bioinformatics

2000 • 59 citations

Sisyphus and prediction of protein structure

1997 • 43 citations

SELEX and the evolution of genomes

1997 • 29 citations

Late-Night Thoughts on the Sequence Annotation Problem

1998 • 28 citations

Unreliability of the Chou-Fasman parameters in predicting protein secondary structure

1998 • 19 citations

Whither genomics?

2000 • 15 citations

From fold recognition to homology modeling: an analysis of protein modeling challenges at different levels of prediction complexity

2000 • 11 citations