Mechanism of Inhibition of Raf-1 by Protein Kinase A

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

1983 • 485 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver

1976 • 295 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

1994 • 218 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

1993 • 180 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Raf-1: A kinase currently without a cause but not lacking in effects

1991 • 155 citations

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

1992 • 142 citations

The Role of Raf-1 Phosphorylation in Signal Transduction

1992 • 136 citations

Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

1993 • 130 citations

Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: Initiation by kinase A and restriction by kinase C

1992 • 46 citations

Transcriptional antagonism of phorbol ester-mediated induction of plasminogen activator inhibitor types 1 and 2 by cyclic adenosine 3',5'-monophosphate.

1992 • 13 citations

Validation of two test systems for detecting tumor promoters and EBV inducers: comparative responses of several agents in DR-CAT Raji cells and in human granulocytes

1993 • 11 citations

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