The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Caspases: Enemies Within

1998 • 6,923 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Morphologic and biochemical hallmarks of apoptosis

2000 • 1,387 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

An alternative, nonapoptotic form of programmed cell death

2000 • 930 citations

The Fas Signaling Pathway: More Than a Paradigm

2002 • 916 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

The autophagosomal–lysosomal compartment in programmed cell death

2001 • 599 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

2002 • 491 citations

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

2002 • 485 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

2000 • 435 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

Intracellular ATP, a switch in the decision between apoptosis and necrosis

1998 • 353 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies

2000 • 332 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

Interdigital cell death can occur through a necrotic and caspase-independent pathway

1999 • 316 citations

Apoptotic and necrotic cell death induced by death domain receptors

2001 • 281 citations

Caspase knockouts: matters of life and death

1999 • 279 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

Necrotic Death Pathway in FAS Receptor Signaling

2000 • 241 citations

Targeted Disruption of TRAF3 Leads to Postnatal Lethality and Defective T-Dependent Immune Responses

1996 • 239 citations

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.

1995 • 227 citations

The roles of Bid.

2002 • 220 citations

Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases

2001 • 217 citations

Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?

1997 • 213 citations

The Survivin saga goes in vivo

2001 • 212 citations

bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

1996 • 212 citations

Cathepsin B Knockout Mice Are Resistant to Tumor Necrosis Factor-α-Mediated Hepatocyte Apoptosis and Liver Injury

2001 • 197 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

Accelerated Atherosclerosis in Mice Lacking Tumor Necrosis Factor Receptor p55

1996 • 183 citations

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

2000 • 173 citations

Generation and Characterization of Smac/DIABLO-Deficient Mice

2002 • 171 citations

TRAF1 Is a Negative Regulator of TNF Signaling

2001 • 170 citations

ATP-dependent steps in apoptotic signal transduction.

1999 • 169 citations

Walther Flemming: pioneer of mitosis research

2001 • 169 citations

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.

1997 • 166 citations

Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury.

2001 • 148 citations

Genetic analysis of the mammalian cell death machinery

2002 • 146 citations

Cell death beyond apoptosis

2000 • 144 citations

baxDeficiency Prevents the Increased Cell Death of Immature Neurons inbcl-x-Deficient Mice

1997 • 143 citations

Prevention of Hepatic Apoptosis and Embryonic Lethality in RelA/TNFR-1 Double Knockout Mice

2000 • 132 citations

Strain-Dependent Neurodevelopmental Abnormalities in Caspase-3-Deficient Mice

2002 • 130 citations

Tumor Necrosis Factor Receptor Deletion Reduces Nuclear Factor-κB Activation, Cellular Inhibitor of Apoptosis Protein 2 Expression, and Functional Recovery after Traumatic Spinal Cord Injury

2001 • 126 citations

Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells

2000 • 122 citations

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

1995 • 117 citations

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice.

1998 • 116 citations

Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?

1999 • 115 citations

Divinations and Surprises: Genetic Analysis of Caspase Function in Mice

2000 • 101 citations

Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways

2002 • 96 citations

Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling

1999 • 78 citations

Elimination of bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells

2001 • 77 citations

TRAF4 Deficiency Leads to Tracheal Malformation with Resulting Alterations in Air Flow to the Lungs

2000 • 77 citations

Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis

1998 • 60 citations

Executionary pathway for apoptosis: lessons from mutant mice

2000 • 44 citations

Apoptosis and age-related disorders: role of caspase-dependent and caspase-independent pathways

2002 • 44 citations

Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death.

2000 • 37 citations

Determination of 2-phenylethylamine in rat brain after MAO inhibitors, and in human CSF and urine by capillary GC and chemical ionization MS

1984 • 31 citations

The bcl‐2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

1998 • 25 citations

Recognition and phagocytosis of apoptotic cells.

1996 • 21 citations

Necrosis has orderly DNA fragmentations

2002 • 19 citations

Fas-independent Apoptosis of Photoreceptor Cells in C3H Mice.

1996 • 17 citations

Regulation of neuronal cell death and differentiation by NGF and IAP family members

2000 • 15 citations