Proapoptotic bax is hyperexpressed in isolated human islets compared with antiapoptotic bcl-21

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1996 • 459 citations

β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia

2002 • 400 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells*

1997 • 302 citations

HUMAN ISLET ISOLATION AND ALLOTRANSPLANTATION IN 22 CONSECUTIVE CASES 1, 2

1992 • 258 citations

Structural and functional changes resulting from islet isolation lead to islet cell death

1999 • 201 citations

Apoptosis in hypoxic human pancreatic islets correlates with HIF‐1α expression

2002 • 179 citations

Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation

1999 • 168 citations

Molecules in focus Bax. The pro-apoptotic Bcl-2 family member, Bax

1998 • 164 citations

Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart

2000 • 149 citations

ENDOTOXIN-MEDIATED DELAYED ISLET GRAFT FUNCTION IS ASSOCIATED WITH INCREASED INTRA-ISLET CYTOKINE PRODUCTION AND ISLET CELL APOPTOSIS1

2001 • 138 citations

Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas

1999 • 134 citations

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

1999 • 125 citations

CYTOPROTECTION OF PANCREATIC ISLETS BEFORE AND SOON AFTER TRANSPLANTATION BY GENE TRANSFER OF THE ANTI-APOPTOTIC Bcl-2 GENE1

2001 • 100 citations

HUMAN PANCREAS PRESERVATION PRIOR TO ISLET ISOLATION

1995 • 99 citations

THE CORRELATION BETWEEN DONOR CHARACTERISTICS AND THE SUCCESS OF HUMAN ISLET ISOLATION1,2

1994 • 92 citations

Tolerance-Inducing Dose of 3-Nitropropionic Acid Modulates bcl-2 and bax Balance in the Rat Brain: A Potential Mechanism of Chemical Preconditioning

2000 • 81 citations

ENDOTOXIN CONTAMINATION MAY BE RESPONSIBLE FOR THE UNEXPLAINED FAILURE OF HUMAN PANCREATIC ISLET TRANSPLANTATION1

1998 • 79 citations

Human islet cell transplantation – future prospects

2001 • 51 citations

Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes

2002 • 50 citations

Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death

1996 • 49 citations

Activation of Human Complement by Collagenase and Ficoll

2009 • 8 citations