Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Automated Method for Isolation of Human Pancreatic Islets

1988 • 1,282 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Cell-Permeable Peptide Inhibitors of JNK

2001 • 581 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Mechanism of p38 MAP kinase activation in vivo

2003 • 466 citations

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1996 • 459 citations

Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene

1998 • 408 citations

Transplantation of Cultured Islets from Two-Layer Preserved Pancreases in Type 1 Diabetes with Anti-CD3 Antibody

2004 • 367 citations

A Peptide Inhibitor of c-Jun N-Terminal Kinase Protects against Both Aminoglycoside and Acoustic Trauma-Induced Auditory Hair Cell Death and Hearing Loss

2003 • 361 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

The regulation of AP-1 activity by mitogen-activated protein kinases

1996 • 312 citations

1. Signal transduction by the c-Jun N-terminal kinase

1999 • 264 citations

Cell Loss in Isolated Human Islets Occurs by Apoptosis

2000 • 237 citations

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.

2000 • 210 citations

Structural and functional changes resulting from islet isolation lead to islet cell death

1999 • 201 citations

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

1998 • 196 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts.

1990 • 184 citations

A SELECTIVE DECREASE IN THE BETA CELL MASS OF HUMAN ISLETS TRANSPLANTED INTO DIABETIC NUDE MICE

1995 • 180 citations

Protection of Islets by in SituPeptide-mediated Transduction of the IκB Kinase Inhibitor Nemo-binding Domain Peptide

2003 • 105 citations

Mammalian MAP kinase modules: how to transduce specific signals.

1997 • 105 citations

Fibroblast Growth Factor Homologous Factors and the Islet Brain-2 Scaffold Protein Regulate Activation of a Stress-activated Protein Kinase

2002 • 104 citations

Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis

2001 • 98 citations

A tripartite anoikis-like mechanism causes early isolated islet apoptosis

2001 • 97 citations

Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets

1996 • 95 citations

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

1995 • 80 citations

Purification and Activation of Recombinant p38 Isoforms α, β, γ, and δ

1998 • 67 citations

cDNA Cloning and Mapping of a Novel Islet-Brain/JNK-Interacting Protein

2000 • 63 citations

Increased Expression and Activation of c-Jun Contributes to Human Amylin-induced Apoptosis in Pancreatic Islet β-Cells

2002 • 63 citations

Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis

2001 • 62 citations

PRIMARY NONFUNCTION OF ISLET GRAFTS IN AUTOIMMUNE DIABETIC NONOBESE DIABETIC MICE IS PREVENTED BY TREATMENT WITH INTERLEUKIN-4 AND INTERLEUKIN-101

1996 • 60 citations

Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival

1994 • 49 citations

Interleukin-1β Stimulation of c-Jun NH2-Terminal Kinase Activity in Insulin-Secreting Cells

2001 • 47 citations

Proapoptotic bax is hyperexpressed in isolated human islets compared with antiapoptotic bcl-21

2002 • 47 citations

THE ROLE OF NITRIC OXIDE IN IL-1β-MEDIATED DYSFUNCTION OF RODENT ISLETS OF LANGERHANS

1994 • 47 citations

Pancreas preservation by the 2-layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitochondrial pathway

2003 • 40 citations

Destruction of islet isografts by severe nonspecific inflammation.

1990 • 34 citations

Successful pancreas preservation before islet isolation by the simplified two-layer cold storage method

2001 • 28 citations

Human Pancreatic Islets Transfected to Produce an Inhibitor of TNF are Protected against Destruction by Human Leukocytes

2000 • 20 citations

MAP Kinases and the Regulation of Nuclear Receptors

2000 • 20 citations

Critical islet mass for successful porcine islet autotrasplantation

1999 • 20 citations

Molecular Mechanisms of Neuronal Cell Death: Implications for Nuclear Factors Responding to cAMP and Phorbol Esters

2002 • 17 citations

Cell‐mediated autoimmunity in type I diabetes

1987 • 16 citations

Interleukin 1-induced Fos and Jun do not regulate inducible nitric oxide synthase in rat islets of Langerhans and RINm5F cells.

1996 • 11 citations