Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

2003 • 1,431 citations

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

2003 • 878 citations

Successful Islet Transplantation

2002 • 727 citations

Cytokines and Their Roles in Pancreatic Islet β-Cell Destruction and Insulin-Dependent Diabetes Mellitus

1998 • 467 citations

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

1993 • 397 citations

Automated Islet Isolation From Human Pancreas

1989 • 369 citations

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

2002 • 285 citations

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

2001 • 263 citations

Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

1998 • 244 citations

Cell Loss in Isolated Human Islets Occurs by Apoptosis

2000 • 237 citations

Protection of Human Islets from the Effects of Interleukin-1β by Adenoviral Gene Transfer of an IκB Repressor

2000 • 210 citations

Intraductal Collagenase Delivery into the Human Pancreas Using Syringe Loading or Controlled Perfusion

1999 • 204 citations

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

2002 • 199 citations

Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation–reduction reactions in innate immunity

2003 • 195 citations

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

2002 • 191 citations

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound

2002 • 176 citations

Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells

2003 • 168 citations

Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution

2003 • 164 citations

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

2003 • 164 citations

Antioxidants, NFκB Activation, and Diabetogenesis

1999 • 155 citations

Recent Advances in the Okamoto Model

2002 • 146 citations

Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase

2000 • 143 citations

Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method

2002 • 125 citations

Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes

2003 • 118 citations

Genetic Engineering of a Suboptimal Islet Graft with A20 Preserves β Cell Mass and Function

2003 • 106 citations

Angiogenic capacity of endothelial cells in islets of Langerhans

2003 • 104 citations

Technical aspects of islet preparation and transplantation

2003 • 98 citations

Impact of two-layer pancreas preservation on islet isolation and transplantation1

2002 • 98 citations

Technical aspects of islet preparation and transplantation

2003 • 92 citations

Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting β-Cells

2003 • 84 citations

Irreversible Inhibition of Metabolic Function and Islet Destruction after a 36-Hour Exposure to Interleukin-1β*

1997 • 71 citations

Pancreatic β-Cell Damage Mediated by β-Cell Production of Interleukin-1

2001 • 66 citations

Oxidative Stress and Insulin Requirements in Patients with Recent-Onset Type 1 Diabetes

2003 • 64 citations

Ouabain Suppresses Glucose-Induced Mitochondrial ATP Production and Insulin Release by Generating Reactive Oxygen Species in Pancreatic Islets

2002 • 63 citations

FUNCTIONAL STUDIES OF RAT, PORCINE, AND HUMAN PANCREATIC ISLETS CULTURED IN TEN COMMERCIALLY AVAILABLE MEDIA

1995 • 58 citations

Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness.

1999 • 58 citations

FUNCTIONAL STUDIES OF RAT, PORCINE, AND HUMAN PANCREATIC ISLETS CULTURED IN TEN COMMERCIALLY AVAILABLE MEDIA

1995 • 56 citations

Flexible Management of Enzymatic Digestion Improves Human Islet Isolation Outcome from Sub‐Optimal Donor Pancreata

2003 • 47 citations

Discrete and Complementary Mechanisms of Protection of β-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy

2003 • 46 citations

Suppression of the c-Jun N-terminal kinase pathway by 17β-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction

2003 • 44 citations

Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents

2003 • 43 citations

Differential transcription of the mouse acute phase serum amyloid A genes in response to pro-inflammatory cytokines

2002 • 32 citations

Administration of NF‐κB decoy inhibits pancreatic activation of NF‐κB and prevents diabetogenesis by alloxan in mice

2001 • 30 citations

DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation

2003 • 25 citations

Deleted Work

1955 • 0 citations