Protein Kinase Cα Is Required for Vanilloid Receptor 1 Activation

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

2000 • 1,715 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

2000 • 1,048 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

1997 • 685 citations

Acid potentiation of the capsaicin receptor determined by a key extracellular site

2000 • 620 citations

Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1995 • 573 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

The Protein Kinase C Family for Neuronal Signaling

1994 • 545 citations

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

2001 • 493 citations

A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice

1999 • 439 citations

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

1996 • 435 citations

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

1999 • 414 citations

VR1 protein expression increases in undamaged DRG neurons after partial nerve injury

2001 • 383 citations

Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C

2000 • 330 citations

Analysis of the Native Quaternary Structure of Vanilloid Receptor 1

2001 • 314 citations

Protons: small stimulants of capsaicin-sensitive sensory nerves

1994 • 305 citations

Epinephrine Produces a β-Adrenergic Receptor-Mediated Mechanical Hyperalgesia and In Vitro Sensitization of Rat Nociceptors

1999 • 284 citations

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

1999 • 261 citations

Ligand-induced Dynamic Membrane Changes and Cell Deletion Conferred by Vanilloid Receptor 1

2001 • 237 citations

The vanilloid receptor (VR1)‐mediated effects of anandamide are potently enhanced by the cAMP‐dependent protein kinase

2001 • 205 citations

The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat

2000 • 190 citations

Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons

2001 • 188 citations

The types of neuron which contain protein kinase C gamma in rat spinal cord

1999 • 186 citations

Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties

2000 • 180 citations

High Density Distribution of Endoplasmic Reticulum Proteins and Mitochondria at Specialized Ca2+ Release Sites in Oligodendrocyte Processes

1997 • 167 citations

Distinct neurochemical features of acute and persistent pain

1999 • 147 citations

Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin

1990 • 138 citations

Anandamide Activates Vanilloid Receptor 1 (VR1) at Acidic pH in Dorsal Root Ganglia Neurons and Cells Ectopically Expressing VR1

2001 • 128 citations

Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology

2000 • 118 citations

Subtype-Specific Translocation of the δ Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells

2001 • 100 citations

Similarities and Differences in the Structure−Activity Relationships of Capsaicin and Resiniferatoxin Analogues

1996 • 89 citations

A Cloning and ϵ-Epitope-Tagging Insert for the Expression of Polymerase Chain Reaction-Generated cDNA Fragments in Escherichia coli and Mammalian Cells

1994 • 64 citations

The effects of phorbol ester on slowly conducting afferents of the cat's knee joint

1993 • 60 citations

G-protein mediation in nociceptive signal transduction: An investigation into the excitatory action of bradykinin in a subpopulation of cultured rat sensory neurons

1992 • 55 citations

The effects of pH on the interaction between capsaicin and the vanilloid receptor in rat dorsal root ganglia neurons

2001 • 51 citations

Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.

1994 • 50 citations

Nerve growth factor activates calcium-insensitive protein kinase C-ɛ in PC-12 rat pheochromocytoma cells

1993 • 46 citations

Rat Brain Protein Kinase C: Purification, Antibody Production, and Quantification in Discrete Regions of Hippocampus

1989 • 46 citations

Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cε

1997 • 37 citations

Neurotrophin action on sensory neurons in adults: an extension of the neurotrophic hypothesis

1999 • 26 citations

Effects of amyloid peptides on cell viability and expression of neuropeptides in cultured rat dorsal root ganglion neurons: a role for free radicals and protein kinase C

2001 • 17 citations

Overexpression of Protein Kinase C-ε and Its Regulatory Domains in Fibroblasts Inhibits Phorbol Ester-Induced Phospholipase D Activity

1999 • 15 citations

Anandamide stimulates phospholipase D activity in PC12 cells but not in NIH 3T3 fibroblasts

1999 • 13 citations

Differential effects of free and liposome‐associated 1‐O‐octadecyl‐2‐O‐methylglycerophosphocholine on protein kinase C

1999 • 6 citations