Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

Control of osteoblast function and regulation of bone mass

2003 • 1,414 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

2000 • 1,024 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

2004 • 758 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Class II histone deacetylases: versatile regulators

2003 • 645 citations

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization

2000 • 595 citations

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

1999 • 539 citations

Does adult fracture repair recapitulate embryonic skeletal formation?

1999 • 537 citations

Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

2000 • 537 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

2001 • 514 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

2001 • 383 citations

Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function

2003 • 322 citations

Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

2001 • 320 citations

Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation

2000 • 303 citations

The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

1998 • 253 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

Cloning and characterization of a histone deacetylase, HDAC9

2001 • 234 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts

1998 • 213 citations

Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo

2001 • 213 citations

HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

2003 • 198 citations

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

2000 • 148 citations

Localization of Smads, the TGF-β Family Intracellular Signaling Components During Endochondral Ossification

1999 • 146 citations

TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation

2004 • 140 citations

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

2000 • 132 citations

Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors

1996 • 108 citations

Smad-Dependent Recruitment of a Histone Deacetylase/Sin3A Complex Modulates the Bone Morphogenetic Protein-Dependent Transcriptional Repressor Activity of Nkx3.2

2003 • 107 citations

Transcriptional Induction of the Osteocalcin Gene During Osteoblast Differentiation Involves Acetylation of Histones H3 and H4

2003 • 93 citations

Synergism between Transcription Factors TFE3 and Smad3 in Transforming Growth Factor-β-induced Transcription of theSmad7 Gene

2000 • 69 citations

An Essential Role for Mad Homology Domain 1 in the Association of Smad3 with Histone Deacetylase Activity*

2001 • 39 citations