Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

1998 • 1,026 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

The MADS-Box Family of Transcription Factors

1995 • 780 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1

1999 • 651 citations

The MADS-Box Family of Transcription Factors

1995 • 645 citations

Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice

1995 • 634 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

1994 • 553 citations

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

1999 • 539 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

2000 • 511 citations

Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

1999 • 510 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

1999 • 450 citations

p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

1999 • 444 citations

Regulation of the MEF2 Family of Transcription Factors by p38

1999 • 429 citations

Drosophila MEF2, a transcription factor that is essential for myogenesis.

1995 • 426 citations

Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.

1996 • 420 citations

The regulation of myogenin gene expression during the embryonic development of the mouse.

1993 • 419 citations

Hormones, Growth Factors, and Myogenic Differentiation

1991 • 399 citations

Skeletal muscle determination and differentiation: story of a core regulatory network and its context

1996 • 372 citations

Molecular Mechanisms of Myogenic Coactivation by p300: Direct Interaction with the Activation Domain of MyoD and with the MADS Box of MEF2C

1997 • 363 citations

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

1998 • 363 citations

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.

1996 • 361 citations

Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program

1999 • 351 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

1999 • 280 citations

Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation

1995 • 274 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

Apoptosis of T Cells Mediated by Ca ²⁺ -Induced Release of the Transcription Factor MEF2

1999 • 262 citations

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

1993 • 258 citations

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors

1999 • 250 citations

Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene.

1988 • 248 citations

Identification of a New Family of Higher Eukaryotic Histone Deacetylases

1999 • 228 citations

A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiae HDA1p

1999 • 227 citations

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage

1993 • 224 citations

Mutational Analysis of the DNA Binding, Dimerization, and Transcriptional Activation Domains of MEF2C

1996 • 203 citations

MEF-2 function is modified by a novel co-repressor, MITR

1999 • 194 citations

Regulatory Role of MEF2D in Serum Induction of the c-jun Promoter

1995 • 176 citations

Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice

1998 • 166 citations

Maturation of the Myogenic Program Is Induced by Postmitotic Expression of Insulin-Like Growth Factor I

1999 • 153 citations

Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle.

1993 • 143 citations

A Dominant-Negative Form of Transcription Factor MEF2 Inhibits Myogenesis

1997 • 130 citations

Failure of Myf5 to Support Myogenic Differentiation without Myogenin, MyoD, and MRF4

2000 • 122 citations

A Unique Phosphorylation-dependent Mechanism for the Activation of Ca2+/Calmodulin-dependent Protein Kinase Type IV/GR

1996 • 112 citations

Identification of Upstream and Intragenic Regulatory Elements That Confer Cell-Type-Restricted and Differentiation-Specific Expression on the Muscle Creatine Kinase Gene

1988 • 86 citations

Defective Survival and Activation of Thymocytes in Transgenic Mice Expressing a Catalytically Inactive Form of Ca2+/Calmodulin-Dependent Protein Kinase IV

1997 • 78 citations

Homeodomain protein MHox and MADS protein myocyte enhancer-binding factor-2 converge on a common element in the muscle creatine kinase enhancer

1994 • 76 citations

Insulin increases near-membrane but not global Ca ²⁺ in isolated skeletal muscle

1999 • 67 citations

The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2.

1994 • 63 citations

Insulin‐like growth factor‐1 enhances rat skeletal muscle charge movement and L‐type Ca²⁺ channel gene expression

1999 • 44 citations

Activation of a Calcium-permeable Cation Channel CD20 Expressed in Balb/c 3T3 Cells by Insulin-like Growth Factor-I

1997 • 39 citations

Multiple Regulatory Elements Contribute Differentially to Muscle Creatine Kinase Enhancer Activity in Skeletal and Cardiac Muscle

1993 • 31 citations

Ca2+/calmodulin-dependent phosphorylation of the 100-kDa protein in chick embryonic muscle cells in culture

1992 • 16 citations

Cyclic AMP Negatively Modulates both Ca2+/Calmodulin-Dependent Phosphorylation of the 100-kDa Protein and Membrane Fusion of Chick Embryonic Myoblasts

1994 • 13 citations