Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Transforming growth factor beta

2011 • 1,990 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Three protein kinase structures define a common motif

1994 • 364 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

TGF-β receptors and actions

1994 • 291 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone.

1994 • 279 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos

1992 • 226 citations

Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors

1993 • 215 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

[17] Identification of receptor for type-β transforming growth factor

1987 • 134 citations

Characterization of type II activin receptors. Binding, processing, and phosphorylation.

1993 • 83 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

1992 • 80 citations

Type I Receptors Specify Growth-Inhibitory and Transcriptional Responses to Transforming Growth Factor β and Activin

1994 • 70 citations

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity.

1992 • 46 citations