Protein transport into mitochondria

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Mitochondrial targeting sequences may form amphiphilic helices.

1986 • 1,019 citations

[Protein import into mitochondria].

2000 • 971 citations

Mitochondrial protein import

1989 • 820 citations

An ancestral mitochondrial DNA resembling a eubacterial genome in miniature

1997 • 633 citations

Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins

1998 • 503 citations

The Preprotein Translocation Channel of the Outer Membrane of Mitochondria

1998 • 392 citations

Mitochondrial Hsp70/MIM44 complex facilitates protein import

1994 • 391 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase

2000 • 374 citations

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

1986 • 340 citations

Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22

1996 • 330 citations

Human deafness dystonia syndrome is a mitochondrial disease

1999 • 326 citations

Role of Tim23 as Voltage Sensor and Presequence Receptor in Protein Import into Mitochondria

1996 • 308 citations

Import of Mitochondrial Carriers Mediated by Essential Proteins of the Intermembrane Space

1998 • 304 citations

Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase

1999 • 301 citations

Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5

1998 • 284 citations

Amphiphilicity is essential for mitochondrial presequence function.

1988 • 274 citations

Can Hsp70 proteins act as force-generating motors?

1995 • 270 citations

The Protein Import System of Mitochondria

1996 • 261 citations

Preprotein Translocase of the Outer Mitochondrial Membrane: Molecular Dissection and Assembly of the General Import Pore Complex

1998 • 250 citations

Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor. Functional implications of the pre sequence for protein transport into mitochondria.

1982 • 249 citations

The Protein Import Motor of Mitochondria

1999 • 242 citations

Oxa1p, an essential component of the N-tail protein export machinery in mitochondria

1998 • 241 citations

The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix.

1984 • 236 citations

The Tom Core Complex

1999 • 218 citations

OXA1, a Saccharomyces cerevisiae Nuclear Gene whose Sequence is Conserved form Prokaryotes to Eukaryotes Controls Cytochrome Oxidase Biogenesis

1994 • 211 citations

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

1998 • 200 citations

Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria.

1996 • 191 citations

Membrane translocation of mitochondrially coded Cox2p: distinct requirements for export of N and C termini and dependence on the conserved protein Oxa1p.

1997 • 186 citations

Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis

1998 • 178 citations

Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria.

1995 • 175 citations

MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria.

1992 • 173 citations

The MIM complex mediates preprotein translocationacross the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system

1995 • 172 citations

Reconstitution of the initial steps of mitochondrial protein import

1995 • 172 citations

Mitochondrial protein import: Reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding

1995 • 171 citations

Insertion into the mitochondrial inner membrane of a polytopic protein, the nuclear-encoded Oxa1p

1997 • 166 citations

MITOCHONDRIAL PREPROTEIN TRANSLOCASE

1997 • 163 citations

The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria.

1987 • 160 citations

Biogenesis of Tom40, Core Component of the Tom Complex of Mitochondria

1999 • 151 citations

Tim9, a new component of the TIM2254 translocase in mitochondria

1999 • 143 citations

PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast

1994 • 135 citations

Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

1999 • 134 citations

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.

1996 • 132 citations

Mitochondrial Protein Import

1997 • 125 citations

The DNA Helicase, Hmi1p, Is Transported into Mitochondria by a C-terminal Cleavable Targeting Signal

1999 • 120 citations

Transport of proteins to the mitochondrial intermembrane space: the ‘sorting’ domain of the cytochrome c1 presequence is a stop-transfer sequence specific for the mitochondrial inner membrane.

1987 • 117 citations

The TIM17middle dot23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix

1999 • 106 citations

The role of the GrpE homologue, Mge1p, in mediating protein import and protein folding in mitochondria.

1995 • 104 citations

Sorting of d-Lactate Dehydrogenase to the Inner Membrane of Mitochondria

1998 • 86 citations

Detection of likely transmembrane β-strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler

1996 • 86 citations

Dynamics of the TOM Complex of Mitochondria during Binding and Translocation of Preproteins

1998 • 82 citations

Conservative sorting of F0-ATPase subunit 9: export from matrix requires delta pH across inner membrane and matrix ATP.

1995 • 79 citations

In Vivo Mitochondrial Import

1999 • 63 citations

Characterization of the Mitochondrial Inner Membrane Translocase Complex: the Tim23p Hydrophobic Domain Interacts with Tim17p but Not with Other Tim23p Molecules

1998 • 61 citations

Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins

1998 • 60 citations

Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane

1998 • 60 citations

Domain structure and lipid interaction of recombinant yeast Tim44

1999 • 59 citations

ADP‐ATP Carrier of Saccharomyces cerevisiae contains a mitochondrial import signal between amino acids 72 and 111

1988 • 53 citations

An unusual mitochondrial import pathway for the precursor to yeast cytochrome c oxidase subunit Va.

1991 • 49 citations

Sorting of Proteins to the Mitochondrial Intermembrane Space

1996 • 2 citations