mTOR Controls FLIP_S Translation and TRAIL Sensitivity in Glioblastoma Multiforme Cells

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Translational control of gene expression

2000 • 1,371 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

Translational control of gene expression

2001 • 1,192 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

2003 • 850 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

2001 • 772 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes

1995 • 654 citations

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 • 651 citations

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

2004 • 611 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex

2001 • 563 citations

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

2003 • 552 citations

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

2001 • 540 citations

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO

2002 • 448 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

Nature's TRAIL—On a Path to Cancer Immunotherapy

2003 • 361 citations

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

2001 • 344 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

B7-H1 pathway and its role in the evasion of tumor immunity

2003 • 272 citations

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

2001 • 268 citations

Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites

1998 • 264 citations

Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation

2003 • 259 citations

Interdimer processing mechanism of procaspase-8 activation

2003 • 259 citations

Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity

2004 • 242 citations

Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation

2002 • 230 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

Locoregional Apo2L/TRAIL Eradicates Intracranial Human Malignant Glioma Xenografts in Athymic Mice in the Absence of Neurotoxicity

1999 • 214 citations

Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells

2002 • 195 citations

APO2 ligand: a novel lethal weapon against malignant glioma?

1998 • 193 citations

Targeted disruption of p70^s6kdefines its role in protein synthesis and rapamycin sensitivity

1998 • 178 citations

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.

2002 • 177 citations

PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1

2003 • 171 citations

Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated Myc

1996 • 164 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

Akt Activation Suppresses Chk2-Mediated, Methylating Agent–Induced G2 Arrest and Protects from Temozolomide-Induced Mitotic Catastrophe and Cellular Senescence

2005 • 148 citations

Shared pathways: Death receptors and cytotoxic drugs in cancer therapy

2001 • 146 citations

The potential of TRAIL for cancer chemotherapy.

2001 • 142 citations

Structural and functional analysis of pp70S6k.

1995 • 126 citations

Convection-Enhanced Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand with Systemic Administration of Temozolomide Prolongs Survival in an Intracranial Glioblastoma Xenograft Model

2004 • 124 citations

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G₂ Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

2003 • 121 citations

Upregulation of FLIP_Sby Akt, a possible inhibition mechanism of TRAIL‐induced apoptosis in human gastric cancers

2003 • 118 citations

Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochromec Release

2003 • 114 citations

Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities

1999 • 103 citations

Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells

2000 • 93 citations

Calcium/Calmodulin-dependent Protein Kinase II Regulation of c-FLIP Expression and Phosphorylation in Modulation of Fas-mediated Signaling in Malignant Glioma Cells

2003 • 88 citations

The short splice form of Casper/c‐FLIP is a major cellular inhibitor of TRAIL‐induced apoptosis

2001 • 70 citations

E1A Sensitizes Cells to Tumor Necrosis Factor Alpha by Downregulating c-FLIP_S

2003 • 66 citations

Cooperative translational control of gene expression by Ras and Akt in cancer

2004 • 57 citations

Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells

2000 • 35 citations

Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells

2004 • 33 citations