Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation

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QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

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G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Translational control of gene expression

2000 • 1,371 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Embryonic Stem Cells Express Neuronal Properties in Vitro

1995 • 1,173 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

PKB/Akt

2001 • 1,066 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 • 908 citations

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

2001 • 772 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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Synthesis of the translational apparatus is regulated at the translational level

2000 • 515 citations

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

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Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

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Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

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PTEN: The down side of PI 3-kinase signalling

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A rapid and convenient assay for counting cells cultured in microwell plates: Application for assessment of growth factors

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The role of c-myc in cellular growth control

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

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Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

2001 • 296 citations

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

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Retinoic Acid Promotes Neural and Represses Mesodermal Gene Expression in Mouse Embryonic Stem Cells in Culture

1996 • 234 citations

An encore for ribosome biogenesis in the control of cell proliferation

2000 • 203 citations

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

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Targeted disruption of p70^s6kdefines its role in protein synthesis and rapamycin sensitivity

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Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

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Characterization of S6K2, a novel kinase homologous to S6K1

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Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element.

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Importance of introns for expression of mouse ribosomal protein gene rpL32.

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Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

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The 5' Terminal Oligopyrimidine Tract Confers Translational Control on Top Mrnas in a Cell Type-and Sequence Context-Dependent Manner

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Extracellular control of cell size

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Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo

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Translational control of mRNA expression during the early mitogenic response in Swiss mouse 3T3 cells: identification of specific proteins.

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Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation.

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22 Translational Control of TOP mRNAs

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Primary Structure, Tissue Distribution, and Expression of Mouse Phosphoinositide-dependent Protein Kinase-1, a Protein Kinase That Phosphorylates and Activates Protein Kinase Cζ

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Growth Factors and Regulation of Cell Growth

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Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver.

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Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase

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Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt

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Nerve and Epidermal Growth Factor Induce Protein Synthesis and eIF2B Activation in PC12 Cells

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The induction of ribosome biosynthesis in a nonmitotic secretory tissue.

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Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.

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Cloning and Characterization of p70S6KβDefines a Novel Family of p70 S6 Kinases

1998 • 49 citations

Mitogenic and Nutritional Signals Are Transduced into Translational Efficiency of TOP mRNAs

2001 • 46 citations

S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells

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Overexpression of poly(A)‐binding protein down‐regulates the translation or the abundance of its own mRNA

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Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α

2001 • 26 citations