Convection-Enhanced Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand with Systemic Administration of Temozolomide Prolongs Survival in an Intracranial Glioblastoma Xenograft Model

Convection-enhanced delivery of macromolecules in the brain.

1994 • 1,357 citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

2002 • 1,325 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

TRAIL and apoptosis induction by TNF-family death receptors

2003 • 843 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

2000 • 526 citations

Criteria for Analyzing Interactions between Biologically Active Agents

1981 • 454 citations

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

2000 • 391 citations

Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL

2000 • 259 citations

Distribution of Liposomes into Brain and Rat Brain Tumor Models by Convection-Enhanced Delivery Monitored with Magnetic Resonance Imaging

2004 • 227 citations

Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma

1997 • 221 citations

Locoregional Apo2L/TRAIL Eradicates Intracranial Human Malignant Glioma Xenografts in Athymic Mice in the Absence of Neurotoxicity

1999 • 214 citations

APO2 ligand: a novel lethal weapon against malignant glioma?

1998 • 193 citations

Activity of temozolomide in the treatment of central nervous system tumor xenografts.

1995 • 145 citations

Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats

2003 • 132 citations

Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells

2001 • 99 citations

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release

2001 • 97 citations

Intracerebral Clysis in a Rat Glioma Model

2000 • 95 citations

Poor-prognosis high-grade gliomas: evolving an evidence-based standard of care

2002 • 91 citations

Neurological complications of antineoplastic therapy.

1984 • 63 citations

Conservative Neurosurgical Management of Intracranial Epidural Abscesses in Children

2003 • 63 citations

Human astrocytic brain tumors express APO2L/TRAIL

1999 • 58 citations