The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G₂ Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

Hard and Soft Acids and Bases

1963 • 9,301 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1997 • 541 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

2001 • 525 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Cell cycle regulation by the Cdc25 phosphatase family

2000 • 433 citations

NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA

1994 • 417 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

1999 • 348 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

2001 • 343 citations

The Pyridinyl Imidazole Inhibitor SB203580 Blocks Phosphoinositide-dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-stimulated T Cells Independently of p38 Mitogen-activated Protein Kinase

2000 • 304 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Activation of Akt/Protein Kinase B Overcomes a G₂/M Cell Cycle Checkpoint Induced by DNA Damage

2002 • 272 citations

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

2001 • 268 citations

Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest

2000 • 251 citations

Current and future developments in the use of temozolomide for the treatment of brain tumours

2001 • 239 citations

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

2001 • 230 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

The mismatch repair system is required for S-phase checkpoint activation

2002 • 196 citations

Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

2001 • 190 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Unmasking a killer: DNA O6-methylguanine and the cytotoxicity of methylating agents

2000 • 185 citations

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1992 • 173 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

1999 • 160 citations

O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.

1998 • 147 citations

DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes

2002 • 112 citations

Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells

1997 • 110 citations

Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific

2002 • 107 citations

Microsatellite Instability and Mutation of DNA Mismatch Repair Genes in Gliomas

1998 • 93 citations

Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38

2002 • 66 citations

Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway

2002 • 63 citations

Temozolomide in malignant gliomas.

2000 • 62 citations

ATM Is Activated in Response toN-Methyl-N′-nitro- N-nitrosoguanidine-induced DNA Alkylation

2002 • 61 citations

Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemic patients

1995 • 53 citations

Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene

2000 • 40 citations

Delayed repletion of O6-methylguanine—DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity

2003 • 39 citations

Future directions in the treatment of malignant gliomas with temozolomide.

2000 • 30 citations

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

1999 • 12 citations

A phase I and II study of pentostatin (Nipent) with cyclophosphamide for previously treated patients with chronic lymphocytic leukemia.

2000 • 4 citations