Upregulation of FLIP_Sby Akt, a possible inhibition mechanism of TRAIL‐induced apoptosis in human gastric cancers

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex

2001 • 563 citations

Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

1999 • 557 citations

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

2000 • 526 citations

Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma.

1999 • 394 citations

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

2000 • 391 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.

2000 • 292 citations

Elevated Akt Activity Protects the Prostate Cancer Cell Line LNCaP from TRAIL-induced Apoptosis

2001 • 272 citations

Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis.

2001 • 195 citations

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

1999 • 195 citations

Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants.

1998 • 184 citations

Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)

2000 • 183 citations

A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis

1999 • 179 citations

Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells

2001 • 108 citations

Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel.

2003 • 78 citations

The short splice form of Casper/c‐FLIP is a major cellular inhibitor of TRAIL‐induced apoptosis

2001 • 70 citations

Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide–Akt–FLIP pathway

2002 • 67 citations

Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin.

1994 • 62 citations

High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells.

2003 • 51 citations

Alternative Splicing Variants of c-FLIP Transduce the Differential Signal through the Raf or TRAF2 in TNF-Induced Cell Proliferation

2001 • 40 citations

Role of antiapoptotic proteins in tumor necrosis factor-related apoptosis-inducing ligand and cisplatin-augmented apoptosis.

2003 • 33 citations

Regulation of tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐induced apoptosis in Burkitt's lymphoma cell lines

2003 • 27 citations

Generation of Fusion Genes Carrying Drug Resistance, Green Fluorescent Protein, and Herpes Simplex Virus Thymidine Kinase Genes in a Single Cistron

2001 • 22 citations

Chelerythrin activates caspase‐8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor‐related apoptosis‐inducing ligand in KG1a cells

2003 • 22 citations