Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

The establishment of polarity by hippocampal neurons in culture

1988 • 1,820 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

1999 • 1,485 citations

Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells

2000 • 1,471 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

NEUROTROPHINS AND SYNAPTIC PLASTICITY

1999 • 1,343 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity

2001 • 1,236 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics

1999 • 1,004 citations

RHO GTPASES in neuronal morphogenesis

2000 • 982 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

Rapid Actin-Based Plasticity in Dendritic Spines

1998 • 920 citations

Dentritic spines : structure, dynamics and regulation

2001 • 915 citations

XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres

1850 • 891 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

2002 • 828 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

ULTRASTRUCTURE AND FUNCTION OF GROWTH CONES AND AXONS OF CULTURED NERVE CELLS

1971 • 769 citations

Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons

2000 • 710 citations

Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation

1997 • 700 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline

1993 • 677 citations

Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin

2002 • 670 citations

Neuronal Polarity

1994 • 658 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

The Dynamics of Dendritic Structure in Developing Hippocampal Slices

1996 • 611 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton

2001 • 546 citations

Signal Transduction in Neuronal Migration

2001 • 541 citations

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

2001 • 537 citations

The Role of Local Actin Instability in Axon Formation

1999 • 526 citations

AXON GROWTH: ROLES OF MICROFILAMENTS AND MICROTUBULES

1970 • 522 citations

Directional guidance of neuronal migration in the olfactory system by the protein Slit

1999 • 517 citations

Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

1999 • 516 citations

Cellular Control of Actin Nucleation

2002 • 507 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

2000 • 498 citations

Dendritic arbor development and synaptogenesis

2001 • 497 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching

1999 • 464 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

Cell motility: can Rho GTPases and microtubules point the way?

2001 • 447 citations

Developmental regulation of spine motility in the mammalian central nervous system

1999 • 422 citations

Regulation of Dendritic Spine Morphology by the Rho Family of Small GTPases: Antagonistic Roles of Rac and Rho

2000 • 420 citations

Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction

1999 • 408 citations

Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones

1996 • 403 citations

High actin concentrations in brain dendritic spines and postsynaptic densities.

1982 • 398 citations

Axon Branching Requires Interactions between Dynamic Microtubules and Actin Filaments

2001 • 394 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

The cell biology of neuronal navigation

2001 • 387 citations

Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment

1986 • 378 citations

The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis

2001 • 375 citations

Growth cone advance is inversely proportional to retrograde F-actin flow

1995 • 371 citations

Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex

1993 • 370 citations

Rho GTPases in growth cone guidance

2001 • 364 citations

Growth of neurites without filopodial or lamellipodial activity in the presence of cytochalasin B.

1984 • 352 citations

Rac function and regulation during Drosophila development

2002 • 346 citations

Dynamic regulation of axon guidance

2001 • 346 citations

Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains.

1992 • 345 citations

Making the connection: Cytoskeletal rearrangements during growth cone guidance

1995 • 343 citations

Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

2001 • 342 citations

Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance

2000 • 339 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

Rac GTPases control axon growth, guidance and branching

2002 • 335 citations

Genes regulating dendritic outgrowth, branching, and routing in Drosophila

1999 • 332 citations

Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient

1996 • 323 citations

Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila

2000 • 315 citations

Cytoplasmic actin in neuronal processes as a possible mediator of synaptic plasticity.

1982 • 306 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

EphB/Syndecan-2 Signaling in Dendritic Spine Morphogenesis

2001 • 303 citations

How do dendrites take their shape?

2001 • 297 citations

Dopaminergic correlates of motivated behavior: importance of drive

1995 • 296 citations

Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo

2000 • 294 citations

Essential Roles of Drosophila RhoA in the Regulation of Neuroblast Proliferation and Dendritic but Not Axonal Morphogenesis

2000 • 291 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

2000 • 289 citations

Cell-Autonomous Requirement of the USP/EcR-B Ecdysone Receptor for Mushroom Body Neuronal Remodeling in Drosophila

2000 • 284 citations

Localized Sources of Neurotrophins Initiate Axon Collateral Sprouting

1998 • 277 citations

Remodeling of Synaptic Actin Induced by Photoconductive Stimulation

2001 • 275 citations

Rho Proteins: Linking Signaling with Membrane Trafficking

2001 • 274 citations

Experimentally induced alteration in the polarity of developing neurons

1987 • 274 citations

Neural reorganization during metamorphosis of the corpora pedunculata in Drosophila melanogaster

1982 • 273 citations

Regulation of Cortical Dendrite Development by Slit-Robo Interactions

2002 • 270 citations

Pioneer growth cone steering decisions mediated by single filopodial contacts in situ

1990 • 268 citations

Navigational errors made by growth cones without filopodia in the embryonic xenopus brain

1993 • 264 citations

The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor.

1993 • 262 citations

SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila

2002 • 257 citations

Do dendritic spines twitch?

1982 • 254 citations

Stages of Synapse Development Defined by Dependence on F-Actin

2001 • 253 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

ThreeC. elegansRac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis

2001 • 244 citations

Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases

2000 • 244 citations

Rapid Dendritic Remodeling in the Developing Retina: Dependence on Neurotransmission and Reciprocal Regulation by Rac and Rho

2000 • 242 citations

Switching Repulsion to Attraction: Changing Responses to Slit During Transition in Mesoderm Migration

2001 • 242 citations

Localized collapsing cues can steer growth cones without inducing their full collapse

1995 • 241 citations

Myosin IIB Is Required for Growth Cone Motility

2001 • 219 citations

Cytoplasmic organization in cerebellar dendritic spines.

1983 • 215 citations

Differences in the organization of actin in the growth cones compared with the neurites of cultured neurons from chick embryos.

1983 • 214 citations

Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice

1986 • 209 citations

Regulating Axon Branch Stability

2001 • 207 citations

Regulation of Rho GTPases by Crosstalk and Neuronal Activity In Vivo

2002 • 207 citations

Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons

2002 • 205 citations

Plexin B Mediates Axon Guidance in Drosophila by Simultaneously Inhibiting Active Rac and Enhancing RhoA Signaling

2001 • 201 citations

Profilin and the Abl Tyrosine Kinase Are Required for Motor Axon Outgrowth in the Drosophila Embryo

1999 • 199 citations

Focal loss of actin bundles causes microtubule redistribution and growth cone turning

2002 • 198 citations

Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells

2002 • 197 citations

Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets

1999 • 196 citations

From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

2000 • 195 citations

Distribution and cellular localization of actin depolymerizing factor.

1987 • 187 citations

Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho

2001 • 187 citations

Increase in Neurite Outgrowth Mediated by Overexpression of Actin Depolymerizing Factor

2000 • 187 citations

Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones

1996 • 183 citations

Localization of myosin II A and B isoforms in cultured neurons

1995 • 180 citations

Dendritic dynamics in vivo change during neuronal maturation.

1999 • 179 citations

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

2000 • 173 citations

Motor proteins regulate force interactions between microtubules and microfilaments in the axon

2000 • 164 citations

Dendritic Reorganization of an Identified Motoneuron During Metamorphosis of the Tobacco Hornworm Moth

1976 • 159 citations

Cdc42hs Facilitates Cytoskeletal Reorganization and Neurite Outgrowth by Localizing the 58-Kd Insulin Receptor Substrate to Filamentous Actin

2001 • 159 citations

Asynchronous Synapse Elimination in Neonatal Motor Units

2001 • 148 citations

Dendritic DynamicsIn VivoChange during Neuronal Maturation

1999 • 147 citations

ChIPping away at potassium channel regulation

2000 • 131 citations

Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling

2001 • 129 citations

Functional Analysis of Cdc42 in Actin Filament Assembly, Epithelial Morphogenesis, and Cell Signaling during Drosophila Development

2000 • 117 citations

Dynamics of target recognition by interstitial axon branching along developing cortical axons

1996 • 115 citations

The role of Notch and Rho GTPase signaling in the control of dendritic development

2001 • 109 citations

Cytochalasin separates microtubule disassembly from loss of asymmetric morphology.

1981 • 105 citations

Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling

2001 • 103 citations

Cellular and molecular features of axon collaterals and dendrites

2000 • 101 citations

A conventional myosin motor drives neurite outgrowth

1998 • 100 citations

Myosin II distribution in neurons is consistent with a role in growth cone motility but not synaptic vesicle mobilization

1992 • 94 citations

Dendrites

2001 • 72 citations

Growth Cone Collapse through Coincident Loss of Actin Bundles and Leading Edge Actin without Actin Depolymerization

2001 • 68 citations

Small GTPases in axon outgrowth.

1996 • 44 citations

Growth cones contain myosin II bipolar filament arrays

2002 • 37 citations