A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Developmental mechanisms that generate precise patterns of neuronal connectivity

1993 • 1,435 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION

1999 • 808 citations

Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons

2000 • 710 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

1999 • 588 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

LIM-kinase1 Hemizygosity Implicated in Impaired Visuospatial Constructive Cognition

1996 • 554 citations

The Role of Local Actin Instability in Axon Formation

1999 • 526 citations

Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

1999 • 516 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42

1997 • 493 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

Cofilin Phosphorylation and Actin Cytoskeletal Dynamics Regulated by Rho- and Cdc42-Activated Lim-Kinase 2

1999 • 384 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

Making the connection: Cytoskeletal rearrangements during growth cone guidance

1995 • 343 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo

2000 • 294 citations

Essential Roles of Drosophila RhoA in the Regulation of Neuroblast Proliferation and Dendritic but Not Axonal Morphogenesis

2000 • 291 citations

Motility and cytoskeletal organization of migrating cerebellar granule neurons

1995 • 277 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro

1991 • 246 citations

A role for rhoB in the delamination of neural crest cells from the dorsal neural tube

1998 • 244 citations

Myosin II activation promotes neurite retraction during the action of Rho and Rho‐kinase

1998 • 243 citations

The Neuronal Architecture ofXenopusRetinal Ganglion Cells Is Sculpted by Rho-Family GTPasesIn Vivo

1999 • 198 citations

Massive Actin Polymerization Induced by Phosphatidylinositol-4-phosphate 5-Kinase in Vivo

1997 • 174 citations

p160 RhoA-binding Kinase ROKα Induces Neurite Retraction

1998 • 166 citations

Drosophila Rac1 controls motor axon guidance

1998 • 144 citations

ChIPping away at potassium channel regulation

2000 • 131 citations

Different Roles for RhoA During Neurite Initiation, Elongation, and Regeneration in PC12 Cells

1999 • 126 citations

Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules

1998 • 119 citations

Development of polarity in cerebellar granule neurons

1997 • 114 citations

Live dynamics of Dictyostelium cofilin suggests a role in remodeling actin latticework into bundles

1997 • 106 citations

Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation

1998 • 101 citations

Functions of netrins and semaphorins in axon guidance

1996 • 98 citations

Overexpression of a Neural-specific Rho Family GTPase, cRac1B, Selectively Induces Enhanced Neuritogenesis and Neurite Branching in Primary Neurons

1998 • 92 citations

Mathematical guidance for axons

1998 • 86 citations

Axon guidance: GTPases help axons reach their targets

1998 • 76 citations

Rac is required for growth cone function but not neurite assembly

1997 • 75 citations

Myosin-dependent contractile activity of the actin cytoskeleton modulates the spatial organization of cell–cell contacts in cultured epitheliocytes

1999 • 63 citations

The Middle and the End

1999 • 41 citations

Histotypic pattern formation in cerebellar reaggregate cultures in the presence of antibodies to L1 cell surface antigen

1985 • 16 citations